STRADA [The Human Chemical-Genetic Interaction Map Project]

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======= STRADA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STRADA
  * **<color #00a2e8>Official Name</color>**: STE20 related adaptor alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92335|92335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7RTN6|Q7RTN6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STRADA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STRADA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608626|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase activator activity|
|protein serine/threonine kinase activator activity|
|kinase binding|
|stress-activated protein kinase signaling cascade|
|cell cycle arrest|
|protein export from nucleus|
|nuclear export|
|protein kinase activity|
|nucleocytoplasmic transport|
|nuclear transport|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|neuron projection development|
|cell morphogenesis|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of kinase activity|
|protein phosphorylation|
|regulation of transferase activity|
|intracellular protein transport|
|cell cycle process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of protein modification process|
|phosphorylation|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.48|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.43|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.23|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.08|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.05|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.97|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.91|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.9|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.89|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.88|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.74|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.73|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.72|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.81|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.85|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.93|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.99|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.26|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.42|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.62|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|5.37|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|6.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:stk11|STK11]]|0.63|
|[[:human genes:p:prkaa1|PRKAA1]]|0.62|
|[[:human genes:p:prkab1|PRKAB1]]|0.614|
|[[:human genes:p:prkag1|PRKAG1]]|0.569|
|[[:human genes:r:rhoa|RHOA]]|0.479|
|[[:human genes:g:gna13|GNA13]]|0.473|
|[[:human genes:r:ric8a|RIC8A]]|0.453|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3204
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STRADA Expression in NALM6 Cells: 5.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>