STX1A [The Human Chemical-Genetic Interaction Map Project]

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======= STX1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX1A
  * **<color #00a2e8>Official Name</color>**: syntaxin 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6804|6804]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16623|Q16623]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186590|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. {ECO:0000250|UniProtKB:P32851}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
|Syntaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin head/neck binding|
|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex|
|synaptobrevin 2-SNAP-25-syntaxin-1a complex|
|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|
|positive regulation of norepinephrine secretion|
|regulation of synaptic vesicle priming|
|ATP-dependent protein binding|
|SNARE complex assembly|
|chloride channel inhibitor activity|
|presynaptic active zone membrane|
|synaptic vesicle docking|
|response to gravity|
|calcium channel inhibitor activity|
|synaptic vesicle fusion to presynaptic active zone membrane|
|positive regulation of catecholamine secretion|
|actomyosin|
|vesicle fusion to plasma membrane|
|regulation of norepinephrine secretion|
|positive regulation of calcium ion-dependent exocytosis|
|positive regulation of neurotransmitter secretion|
|positive regulation of excitatory postsynaptic potential|
|glutamate secretion|
|SNAP receptor activity|
|integral component of synaptic vesicle membrane|
|positive regulation of amine transport|
|positive regulation of neurotransmitter transport|
|insulin secretion|
|modulation of excitatory postsynaptic potential|
|vesicle docking involved in exocytosis|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|acidic amino acid transport|
|SNARE complex|
|synaptic vesicle recycling|
|positive regulation of regulated secretory pathway|
|integral component of presynaptic membrane|
|peptide hormone secretion|
|calcium-dependent protein binding|
|regulation of catecholamine secretion|
|positive regulation of nervous system process|
|vesicle docking|
|synaptic vesicle exocytosis|
|SNARE binding|
|protein sumoylation|
|exocytic process|
|vesicle fusion|
|hormone secretion|
|presynaptic membrane|
|endomembrane system|
|organelle membrane fusion|
|regulation of synaptic vesicle exocytosis|
|protein binding, bridging|
|dicarboxylic acid transport|
|acid secretion|
|hormone transport|
|voltage-gated potassium channel complex|
|secretory granule|
|positive regulation of exocytosis|
|kinase binding|
|regulation of amine transport|
|organelle fusion|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|protein N-terminus binding|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|amino acid transport|
|synaptic vesicle|
|ion channel binding|
|vesicle-mediated transport in synapse|
|membrane fusion|
|regulation of nervous system process|
|regulation of neurotransmitter transport|
|positive regulation of synaptic transmission|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|signal release|
|organelle localization by membrane tethering|
|peptide secretion|
|regulation of insulin secretion|
|membrane docking|
|neurotransmitter transport|
|regulation of peptide hormone secretion|
|regulation of exocytosis|
|nuclear membrane|
|protein domain specific binding|
|postsynaptic density|
|regulation of hormone secretion|
|carboxylic acid transport|
|organic acid transport|
|axon|
|vesicle organization|
|peptidyl-lysine modification|
|neuron projection|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of secretion by cell|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|organic anion transport|
|synaptic signaling|
|regulation of protein secretion|
|protein localization to membrane|
|protein heterodimerization activity|
|regulation of peptide secretion|
|regulation of hormone levels|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|organelle localization|
|anion transport|
|regulation of system process|
|cytokine-mediated signaling pathway|
|import into cell|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|protein modification by small protein conjugation|
|exocytosis|
|regulation of secretion|
|cellular protein-containing complex assembly|
|membrane organization|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|intracellular protein transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|identical protein binding|
|response to cytokine|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17800
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX1A Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>