STX1B [The Human Chemical-Genetic Interaction Map Project]

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======= STX1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX1B
  * **<color #00a2e8>Official Name</color>**: syntaxin 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112755|112755]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61266|P61266]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601485|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
|Syntaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of macropinocytosis|
|positive regulation of spontaneous neurotransmitter secretion|
|negative regulation of synaptic vesicle recycling|
|regulation of spontaneous neurotransmitter secretion|
|regulation of synaptic activity|
|regulation of macropinocytosis|
|regulation of spontaneous synaptic transmission|
|negative regulation of pinocytosis|
|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|
|spontaneous neurotransmitter secretion|
|spontaneous synaptic transmission|
|regulation of synaptic vesicle priming|
|synaptic vesicle docking|
|regulation of pinocytosis|
|presynaptic active zone membrane|
|synaptic vesicle fusion to presynaptic active zone membrane|
|vesicle fusion to plasma membrane|
|neurotransmitter receptor transport to postsynaptic membrane|
|neurotransmitter receptor transport to plasma membrane|
|establishment of protein localization to postsynaptic membrane|
|calcium ion-regulated exocytosis of neurotransmitter|
|positive regulation of neurotransmitter secretion|
|regulation of synaptic vesicle recycling|
|positive regulation of excitatory postsynaptic potential|
|SNAP receptor activity|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|positive regulation of neurotransmitter transport|
|modulation of excitatory postsynaptic potential|
|receptor localization to synapse|
|calcium-ion regulated exocytosis|
|vesicle docking involved in exocytosis|
|negative regulation of endocytosis|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|SNARE complex|
|protein localization to synapse|
|vesicle docking|
|positive regulation of nervous system process|
|synaptic vesicle exocytosis|
|SNARE binding|
|exocytic process|
|vesicle fusion|
|presynaptic membrane|
|endomembrane system|
|neuromuscular junction|
|organelle membrane fusion|
|regulation of synaptic vesicle exocytosis|
|vesicle-mediated transport to the plasma membrane|
|organelle fusion|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|spindle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|membrane fusion|
|regulation of nervous system process|
|regulation of neurotransmitter transport|
|positive regulation of synaptic transmission|
|negative regulation of neuron projection development|
|microtubule organizing center|
|regulation of regulated secretory pathway|
|signal release|
|organelle localization by membrane tethering|
|neurotransmitter transport|
|membrane docking|
|negative regulation of cell projection organization|
|regulation of endocytosis|
|regulation of exocytosis|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|protein localization to cell periphery|
|protein domain specific binding|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|negative regulation of neurogenesis|
|axon|
|vesicle organization|
|negative regulation of nervous system development|
|negative regulation of cell development|
|signaling receptor binding|
|regulation of neurotransmitter levels|
|positive regulation of secretion by cell|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|synaptic signaling|
|protein kinase binding|
|protein localization to membrane|
|negative regulation of transport|
|regulation of neuron projection development|
|regulation of vesicle-mediated transport|
|organelle localization|
|regulation of system process|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|membrane organization|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|intracellular protein transport|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|negative regulation of multicellular organismal process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX1B Expression in NALM6 Cells: 1.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>