STX5 [The Human Chemical-Genetic Interaction Map Project]

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======= STX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX5
  * **<color #00a2e8>Official Name</color>**: syntaxin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6811|6811]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13190|Q13190]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603189|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. {ECO:0000250|UniProtKB:Q08851}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
|Syntaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi disassembly|
|vesicle fusion with Golgi apparatus|
|Golgi inheritance|
|organelle inheritance|
|early endosome to Golgi transport|
|regulation of Golgi organization|
|SNAP receptor activity|
|SNARE complex|
|ER to Golgi transport vesicle membrane|
|vesicle docking|
|vesicle targeting, rough ER to cis-Golgi|
|COPII vesicle coating|
|organelle disassembly|
|SNARE binding|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|vesicle fusion|
|endomembrane system|
|Golgi vesicle budding|
|organelle membrane fusion|
|vesicle targeting|
|retrograde transport, endosome to Golgi|
|organelle fusion|
|vesicle budding from membrane|
|protein N-terminus binding|
|membrane fusion|
|Golgi organization|
|vesicle|
|cytosolic transport|
|organelle localization by membrane tethering|
|establishment of vesicle localization|
|membrane docking|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|positive regulation of protein catabolic process|
|endosomal transport|
|vesicle organization|
|cadherin binding|
|establishment of organelle localization|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|cellular component disassembly|
|endomembrane system organization|
|positive regulation of catabolic process|
|organelle localization|
|Golgi membrane|
|membrane organization|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|intracellular protein transport|
|regulation of catabolic process|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.72|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 338/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|12/28|
|bone|15/26|
|breast|19/33|
|central nervous system|25/56|
|cervix|3/4|
|colorectal|9/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|12/21|
|liver|10/20|
|lung|32/75|
|lymphocyte|7/16|
|ovary|14/26|
|pancreas|8/24|
|peripheral nervous system|8/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|10/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3743
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX5 Expression in NALM6 Cells: 4.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>