STXBP5L [The Human Chemical-Genetic Interaction Map Project]

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======= STXBP5L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STXBP5L
  * **<color #00a2e8>Official Name</color>**: syntaxin binding protein 5 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9515|9515]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2K9|Q9Y2K9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STXBP5L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STXBP5L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609381|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is similar to syntaxin-binding protein 5 and contains ten N-terminal WD40 repeats, four variable region WD40 repeats, and a C-terminal R-SNARE domain. Studies of the orthologous proteins in mouse and rat have shown that the encoded protein may inhibit exocytosis in neurosecretory cells, and may negatively regulate the secretion of insulin. A missense variant in this gene is likely the cause of an infantile-onset neurodegenerative disorder diagnosed in two siblings of consanguineous parents. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in vesicle trafficking and exocytosis. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LLGL|
|Lgl C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuronal dense core vesicle|
|myosin II binding|
|negative regulation of insulin secretion|
|negative regulation of peptide hormone secretion|
|SNARE complex|
|syntaxin binding|
|negative regulation of hormone secretion|
|neuromuscular junction|
|regulation of synaptic vesicle exocytosis|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of neurotransmitter transport|
|Rab GTPase binding|
|regulation of regulated secretory pathway|
|regulation of insulin secretion|
|negative regulation of protein transport|
|glucose homeostasis|
|carbohydrate homeostasis|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|regulation of exocytosis|
|negative regulation of secretion|
|regulation of hormone secretion|
|GTPase activator activity|
|regulation of neurotransmitter levels|
|positive regulation of GTPase activity|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein secretion|
|regulation of GTPase activity|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|exocytosis|
|regulation of secretion|
|regulation of cellular localization|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|chemical homeostasis|
|secretion|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|positive regulation of molecular function|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6463
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STXBP5L Expression in NALM6 Cells: 1.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>