SUCLG1 [The Human Chemical-Genetic Interaction Map Project]

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======= SUCLG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUCLG1
  * **<color #00a2e8>Official Name</color>**: succinate-CoA ligase GDP/ADP-forming subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8802|8802]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53597|P53597]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUCLG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUCLG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611224|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. {ECO:0000255|HAMAP- Rule:MF_03222}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ligase CoA|
|CoA binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|succinate-CoA ligase (GDP-forming) activity|
|succinate-CoA ligase (ADP-forming) activity|
|succinyl-CoA metabolic process|
|succinate metabolic process|
|cofactor binding|
|nucleoside diphosphate kinase activity|
|tricarboxylic acid cycle|
|nucleoside diphosphate phosphorylation|
|nucleotide binding|
|nucleotide phosphorylation|
|nucleoside triphosphate biosynthetic process|
|aerobic respiration|
|nucleoside diphosphate metabolic process|
|nucleoside triphosphate metabolic process|
|dicarboxylic acid metabolic process|
|acyl-CoA metabolic process|
|thioester metabolic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|cellular respiration|
|energy derivation by oxidation of organic compounds|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-3.28|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-3.2|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-3.13|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.9|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.57|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.46|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|-2.33|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.32|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.32|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.25|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.25|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.92|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.85|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.85|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.82|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.76|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.74|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.7|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.74|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.77|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.78|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.84|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.89|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.89|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.04|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.06|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.37|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|5.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sucla2|SUCLA2]]|0.627|
|[[:human genes:g:glrx5|GLRX5]]|0.569|
|[[:human genes:a:abhd11|ABHD11]]|0.483|
|[[:human genes:i:iba57|IBA57]]|0.422|
|[[:human genes:i:isca2|ISCA2]]|0.418|
|[[:human genes:n:nfu1|NFU1]]|0.411|
|[[:human genes:g:gcsh|GCSH]]|0.409|
|[[:human genes:l:lipt2|LIPT2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5184
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUCLG1 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>