SUGT1 [The Human Chemical-Genetic Interaction Map Project]

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======= SUGT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUGT1
  * **<color #00a2e8>Official Name</color>**: SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10910|10910]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Z0|Q9Y2Z0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUGT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUGT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604098|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SGS|
|CS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of catalytic activity in other organism involved in symbiotic interaction|
|positive regulation by host of symbiont catalytic activity|
|modulation by host of symbiont catalytic activity|
|modulation of catalytic activity in other organism involved in symbiotic interaction|
|negative regulation by host of symbiont molecular function|
|modulation by host of symbiont molecular function|
|negative regulation of molecular function in other organism|
|negative regulation of molecular function in other organism involved in symbiotic interaction|
|modulation of molecular function in other organism involved in symbiotic interaction|
|modulation of molecular function in other organism|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|kinetochore|
|ubiquitin ligase complex|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|modification of morphology or physiology of other organism|
|protein stabilization|
|regulation of protein stability|
|protein-containing complex|
|mitotic cell cycle|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of molecular function|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-3.95|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.87|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-2.86|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.57|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.37|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.19|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.14|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.13|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.11|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.11|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.08|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.99|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.98|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.93|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.93|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.91|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.9|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.87|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.83|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.82|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.82|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.82|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.81|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.71|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.74|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.97|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.04|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.23|
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpp21|RPP21]]|0.447|
|[[:human genes:d:ddx20|DDX20]]|0.434|
|[[:human genes:v:vezt|VEZT]]|0.429|
|[[:human genes:g:gemin8|GEMIN8]]|0.418|
|[[:human genes:h:haus8|HAUS8]]|0.418|
|[[:human genes:o:osgep|OSGEP]]|0.415|
|[[:human genes:s:srpk1|SRPK1]]|0.413|
|[[:human genes:n:nsmce1|NSMCE1]]|0.411|
|[[:human genes:t:thoc3|THOC3]]|0.401|
|[[:human genes:r:rnmt|RNMT]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 94/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|3/28|
|bone|6/26|
|breast|2/33|
|central nervous system|11/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|0/16|
|kidney|2/21|
|liver|4/20|
|lung|14/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6068
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUGT1 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>