SULT1A3 [The Human Chemical-Genetic Interaction Map Project]

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======= SULT1A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SULT1A3
  * **<color #00a2e8>Official Name</color>**: sulfotransferase family 1A member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6818|6818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DMM9|P0DMM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SULT1A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SULT1A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600641|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfotransfer 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|amine sulfotransferase activity|
|NMDA selective glutamate receptor signaling pathway|
|sulfate binding|
|aryl sulfotransferase activity|
|dopamine catabolic process|
|catechol-containing compound catabolic process|
|catecholamine catabolic process|
|ethanol catabolic process|
|phenol-containing compound catabolic process|
|calcineurin-mediated signaling|
|primary alcohol catabolic process|
|flavonoid metabolic process|
|sulfation|
|ethanol metabolic process|
|3-phosphoadenosine 5-phosphosulfate metabolic process|
|ionotropic glutamate receptor signaling pathway|
|purine ribonucleoside bisphosphate metabolic process|
|ERK1 and ERK2 cascade|
|dopamine metabolic process|
|sulfotransferase activity|
|dopamine receptor signaling pathway|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|glutamate receptor signaling pathway|
|antibiotic catabolic process|
|alcohol catabolic process|
|IRE1-mediated unfolded protein response|
|organic hydroxy compound catabolic process|
|primary alcohol metabolic process|
|phenol-containing compound metabolic process|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|antibiotic metabolic process|
|endoplasmic reticulum unfolded protein response|
|response to monoamine|
|response to catecholamine|
|cellular response to unfolded protein|
|cellular response to ammonium ion|
|xenobiotic metabolic process|
|ribonucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|drug catabolic process|
|calcium-mediated signaling|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|response to topologically incorrect protein|
|ammonium ion metabolic process|
|negative regulation of neuron death|
|response to endoplasmic reticulum stress|
|steroid metabolic process|
|response to xenobiotic stimulus|
|regulation of neuron death|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|cellular response to drug|
|small molecule catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|organophosphate metabolic process|
|response to organic cyclic compound|
|protein phosphorylation|
|negative regulation of cell death|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.57|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.468|
|[[:human genes:a:aatf|AATF]]|0.46|
|[[:human genes:t:twistnb|TWISTNB]]|0.454|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.448|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.445|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.445|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.445|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.444|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.444|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.441|
|[[:human genes:t:tceb3c|TCEB3C]]|0.441|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.438|
|[[:human genes:p:polr2d|POLR2D]]|0.437|
|[[:human genes:s:slc6a17|SLC6A17]]|0.436|
|[[:human genes:d:ddtl|DDTL]]|0.436|
|[[:human genes:c:chd4|CHD4]]|0.434|
|[[:human genes:p:pan2|PAN2]]|0.432|
|[[:human genes:p:psmd3|PSMD3]]|0.431|
|[[:human genes:p:psmb4|PSMB4]]|0.429|
|[[:human genes:r:rps2|RPS2]]|0.429|
|[[:human genes:p:psmd11|PSMD11]]|0.428|
|[[:human genes:s:slc38a7|SLC38A7]]|0.426|
|[[:human genes:c:copg1|COPG1]]|0.425|
|[[:human genes:o:orc1|ORC1]]|0.425|
|[[:human genes:p:psmb2|PSMB2]]|0.425|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.418|
|[[:human genes:p:psmd2|PSMD2]]|0.418|
|[[:human genes:e:exosc5|EXOSC5]]|0.416|
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.414|
|[[:human genes:u:upf1|UPF1]]|0.414|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.413|
|[[:human genes:p:pwp2|PWP2]]|0.412|
|[[:human genes:v:vasn|VASN]]|0.412|
|[[:human genes:f:fcn2|FCN2]]|0.411|
|[[:human genes:p:psmc2|PSMC2]]|0.409|
|[[:human genes:v:vps28|VPS28]]|0.409|
|[[:human genes:b:bysl|BYSL]]|0.406|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.406|
|[[:human genes:p:psma6|PSMA6]]|0.406|
|[[:human genes:p:pola1|POLA1]]|0.405|
|[[:human genes:r:rps19|RPS19]]|0.403|
|[[:human genes:p:prim1|PRIM1]]|0.402|
|[[:human genes:s:syt9|SYT9]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2723
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SULT1A3 Expression in NALM6 Cells: 3.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>