SUPT7L [The Human Chemical-Genetic Interaction Map Project]

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======= SUPT7L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUPT7L
  * **<color #00a2e8>Official Name</color>**: SPT7 like, STAGA complex subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9913|9913]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94864|O94864]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUPT7L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUPT7L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612762|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bromo TP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|STAGA complex|
|maintenance of protein location in nucleus|
|maintenance of protein localization in organelle|
|histone H3 acetylation|
|histone acetyltransferase activity|
|maintenance of protein location in cell|
|maintenance of location in cell|
|maintenance of protein location|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein localization to nucleus|
|maintenance of location|
|protein acylation|
|transcription coactivator activity|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|protein heterodimerization activity|
|chromatin organization|
|protein localization to organelle|
|peptidyl-amino acid modification|
|chromosome organization|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.47|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.1|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-2.03|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.98|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.96|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.86|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.76|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.7|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.71|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.88|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.92|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.02|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.95|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tada2b|TADA2B]]|0.725|
|[[:human genes:t:taf5l|TAF5L]]|0.689|
|[[:human genes:t:taf6l|TAF6L]]|0.673|
|[[:human genes:t:tada1|TADA1]]|0.625|
|[[:human genes:t:tada3|TADA3]]|0.575|
|[[:human genes:c:ccdc101|CCDC101]]|0.558|
|[[:human genes:m:med13l|MED13L]]|0.539|
|[[:human genes:m:med13|MED13]]|0.533|
|[[:human genes:a:atxn7|ATXN7]]|0.524|
|[[:human genes:k:kat2a|KAT2A]]|0.509|
|[[:human genes:u:usp22|USP22]]|0.501|
|[[:human genes:m:mllt1|MLLT1]]|0.497|
|[[:human genes:m:med23|MED23]]|0.495|
|[[:human genes:s:supt20h|SUPT20H]]|0.487|
|[[:human genes:h:hdac8|HDAC8]]|0.481|
|[[:human genes:b:brpf1|BRPF1]]|0.461|
|[[:human genes:t:tle4|TLE4]]|0.456|
|[[:human genes:i:id3|ID3]]|0.445|
|[[:human genes:m:med25|MED25]]|0.445|
|[[:human genes:t:tceb3|TCEB3]]|0.436|
|[[:human genes:z:znf592|ZNF592]]|0.413|
|[[:human genes:m:mapk14|MAPK14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2416
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUPT7L Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>