SUV39H1 [The Human Chemical-Genetic Interaction Map Project]

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======= SUV39H1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUV39H1
  * **<color #00a2e8>Official Name</color>**: suppressor of variegation 3-9 homolog 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6839|6839]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43463|O43463]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUV39H1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUV39H1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300254|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. {ECO:0000269|PubMed:14765126, ECO:0000269|PubMed:16449642, ECO:0000269|PubMed:16818776, ECO:0000269|PubMed:16858404, ECO:0000269|PubMed:18004385, ECO:0000269|PubMed:18485871}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pre-SET|
|SET|
|Chromo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-K9 dimethylation|
|histone H3-K9 trimethylation|
|rDNA heterochromatin|
|chromatin silencing complex|
|nuclear lamina|
|histone methyltransferase activity (H3-K9 specific)|
|histone methyltransferase activity|
|S-adenosylmethionine-dependent methyltransferase activity|
|chromatin silencing at rDNA|
|peptidyl-lysine dimethylation|
|histone H3-K9 methylation|
|negative regulation of circadian rhythm|
|histone H3-K9 modification|
|histone-lysine N-methyltransferase activity|
|heterochromatin|
|condensed nuclear chromosome|
|peptidyl-lysine trimethylation|
|chromosome, centromeric region|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|chromatin organization involved in regulation of transcription|
|histone lysine methylation|
|transcription regulatory region sequence-specific DNA binding|
|negative regulation of gene expression, epigenetic|
|peptidyl-lysine methylation|
|histone methylation|
|protein N-terminus binding|
|regulation of circadian rhythm|
|protein methylation|
|protein alkylation|
|gene silencing|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|rRNA processing|
|cellular response to oxygen levels|
|rRNA metabolic process|
|regulation of gene expression, epigenetic|
|macromolecule methylation|
|rhythmic process|
|ribosome biogenesis|
|methylation|
|peptidyl-lysine modification|
|response to hypoxia|
|response to decreased oxygen levels|
|histone modification|
|covalent chromatin modification|
|response to oxygen levels|
|ncRNA processing|
|chromatin binding|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|chromatin organization|
|viral process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|peptidyl-amino acid modification|
|chromosome organization|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|negative regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.24|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.03|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.71|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.79|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|3.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc38a1|SLC38A1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16763
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUV39H1 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>