SYCP1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SYCP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYCP1
  * **<color #00a2e8>Official Name</color>**: synaptonemal complex protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6847|6847]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15431|Q15431]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYCP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYCP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602162|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. {ECO:0000250|UniProtKB:Q62209}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SCP-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lateral element assembly|
|transverse filament|
|meiotic DNA repair synthesis|
|chiasma assembly|
|central element|
|sperm chromatin condensation|
|male germ cell nucleus|
|synaptonemal complex assembly|
|spermatid nucleus differentiation|
|synaptonemal complex organization|
|synaptonemal complex|
|synapsis|
|DNA synthesis involved in DNA repair|
|reciprocal meiotic recombination|
|homologous recombination|
|chromosome, centromeric region|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|meiotic chromosome segregation|
|protein homotetramerization|
|double-stranded DNA binding|
|meiosis I|
|DNA biosynthetic process|
|meiosis I cell cycle process|
|nucleus organization|
|protein tetramerization|
|spermatid development|
|meiotic nuclear division|
|spermatid differentiation|
|meiotic cell cycle process|
|DNA packaging|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|germ cell development|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|protein homooligomerization|
|cellular process involved in reproduction in multicellular organism|
|cell division|
|DNA repair|
|protein complex oligomerization|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|regulation of protein localization|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cell development|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16499
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYCP1 Expression in NALM6 Cells: -0.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>