SYMPK [The Human Chemical-Genetic Interaction Map Project]

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======= SYMPK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYMPK
  * **<color #00a2e8>Official Name</color>**: symplekin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8189|8189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92797|Q92797]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYMPK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYMPK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602388|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house- keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. {ECO:0000269|PubMed:16230528, ECO:0000269|PubMed:20861839}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Symplekin C|
|DUF3453|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear stress granule|
|mRNA polyadenylation|
|RNA polyadenylation|
|termination of RNA polymerase II transcription|
|positive regulation of protein dephosphorylation|
|positive regulation of dephosphorylation|
|DNA-templated transcription, termination|
|mRNA 3-end processing|
|negative regulation of protein binding|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|bicellular tight junction|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|regulation of protein dephosphorylation|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|negative regulation of binding|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|regulation of dephosphorylation|
|RNA localization|
|regulation of protein binding|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|cytoskeleton|
|regulation of binding|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|cell adhesion|
|biological adhesion|
|intracellular protein transport|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 593/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|19/28|
|bone|20/26|
|breast|30/33|
|central nervous system|41/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|14/21|
|liver|14/20|
|lung|60/75|
|lymphocyte|15/16|
|ovary|23/26|
|pancreas|20/24|
|peripheral nervous system|14/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1240
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYMPK Expression in NALM6 Cells: 7.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>