SYT2 [The Human Chemical-Genetic Interaction Map Project]

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======= SYT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYT2
  * **<color #00a2e8>Official Name</color>**: synaptotagmin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=127833|127833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N9I0|Q8N9I0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600104|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a synaptic vesicle membrane protein. The encoded protein is thought to function as a calcium sensor in vesicular trafficking and exocytosis. Mutations in this gene are associated with myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:P46097, ECO:0000269|PubMed:23999003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol 1,3,4,5 tetrakisphosphate binding|
|chromaffin granule membrane|
|dense core granule|
|calcium ion-regulated exocytosis of neurotransmitter|
|positive regulation of dendrite extension|
|regulation of dendrite extension|
|exocytic vesicle|
|clathrin binding|
|regulation of dopamine secretion|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|synaptic vesicle recycling|
|clathrin-coated vesicle membrane|
|syntaxin binding|
|calcium-dependent phospholipid binding|
|phosphatidylserine binding|
|regulation of catecholamine secretion|
|synaptic vesicle exocytosis|
|SNARE binding|
|synaptic vesicle membrane|
|cellular response to calcium ion|
|regulation of amine transport|
|regulation of response to drug|
|neurotransmitter secretion|
|signal release from synapse|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|response to calcium ion|
|regulation of regulated secretory pathway|
|positive regulation of cell growth|
|signal release|
|positive regulation of developmental growth|
|neurotransmitter transport|
|cellular response to metal ion|
|cellular response to inorganic substance|
|regulation of exocytosis|
|positive regulation of growth|
|positive regulation of neuron projection development|
|axon|
|regulation of developmental growth|
|regulation of neurotransmitter levels|
|positive regulation of neuron differentiation|
|response to metal ion|
|positive regulation of cell projection organization|
|regulation of cell growth|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|regulation of neuron differentiation|
|regulation of growth|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulated exocytosis|
|regulation of cell projection organization|
|calcium ion binding|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|membrane organization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3557
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYT2 Expression in NALM6 Cells: 1.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>