SYT6 [The Human Chemical-Genetic Interaction Map Project]

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======= SYT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYT6
  * **<color #00a2e8>Official Name</color>**: synaptotagmin 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=148281|148281]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T7P8|Q5T7P8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607718|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250|UniProtKB:Q9R0N8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuronal dense core vesicle exocytosis|
|presynaptic dense core vesicle exocytosis|
|integral component of synaptic membrane|
|acrosomal vesicle exocytosis|
|dense core granule exocytosis|
|perinuclear endoplasmic reticulum|
|calcium ion-regulated exocytosis of neurotransmitter|
|acrosome reaction|
|exocytic vesicle|
|clathrin binding|
|regulation of dopamine secretion|
|calcium-ion regulated exocytosis|
|regulation of calcium ion-dependent exocytosis|
|syntaxin binding|
|calcium-dependent phospholipid binding|
|phosphatidylserine binding|
|calcium-dependent protein binding|
|regulation of catecholamine secretion|
|synaptic vesicle exocytosis|
|extrinsic component of membrane|
|SNARE binding|
|synaptic vesicle membrane|
|cellular response to calcium ion|
|regulation of amine transport|
|regulation of response to drug|
|neurotransmitter secretion|
|signal release from synapse|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|single fertilization|
|response to calcium ion|
|regulation of regulated secretory pathway|
|signal release|
|fertilization|
|neurotransmitter transport|
|cellular response to metal ion|
|cellular response to inorganic substance|
|regulation of exocytosis|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|response to metal ion|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|response to inorganic substance|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of ion transport|
|regulated exocytosis|
|calcium ion binding|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|sexual reproduction|
|protein homodimerization activity|
|multi-organism reproductive process|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|reproductive process|
|reproduction|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4208
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYT6 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>