SYTL4 [The Human Chemical-Genetic Interaction Map Project]

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======= SYTL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SYTL4
  * **<color #00a2e8>Official Name</color>**: synaptotagmin like 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=94121|94121]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96C24|Q96C24]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SYTL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SYTL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300723|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of plasma membrane repair|
|plasma membrane repair|
|neurexin family protein binding|
|regulation of plasma membrane organization|
|platelet alpha granule membrane|
|exocytic vesicle|
|multivesicular body sorting pathway|
|negative regulation of insulin secretion|
|transport vesicle membrane|
|lysosome localization|
|negative regulation of peptide hormone secretion|
|negative regulation of hormone secretion|
|extrinsic component of membrane|
|positive regulation of exocytosis|
|plasma membrane organization|
|phospholipid binding|
|platelet degranulation|
|negative regulation of protein secretion|
|regulation of wound healing|
|negative regulation of peptide secretion|
|Rab GTPase binding|
|microtubule organizing center|
|regulation of response to wounding|
|regulation of insulin secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|regulation of exocytosis|
|negative regulation of secretion|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|endosome|
|positive regulation of peptide secretion|
|positive regulation of secretion by cell|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|wound healing|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|response to wounding|
|organelle localization|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|membrane organization|
|positive regulation of transport|
|intracellular protein transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|secretion|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.8|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10071
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SYTL4 Expression in NALM6 Cells: 2.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>