TAB1 [The Human Chemical-Genetic Interaction Map Project]

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======= TAB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAB1
  * **<color #00a2e8>Official Name</color>**: TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10454|10454]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15750|Q15750]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602615|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP2C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitogen-activated protein kinase p38 binding|
|activation of MAPKKK activity|
|magnesium-dependent protein serine/threonine phosphatase activity|
|nucleotide-binding oligomerization domain containing signaling pathway|
|protein kinase activator activity|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|MyD88-dependent toll-like receptor signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|coronary vasculature development|
|enzyme activator activity|
|aorta development|
|protein serine/threonine phosphatase activity|
|I-kappaB kinase/NF-kappaB signaling|
|JNK cascade|
|artery development|
|interleukin-1-mediated signaling pathway|
|toll-like receptor signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|stress-activated MAPK cascade|
|cardiac septum development|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|pattern recognition receptor signaling pathway|
|stress-activated protein kinase signaling cascade|
|positive regulation of NF-kappaB transcription factor activity|
|cellular response to transforming growth factor beta stimulus|
|activation of MAPK activity|
|response to transforming growth factor beta|
|intracellular receptor signaling pathway|
|lung development|
|cardiac chamber development|
|respiratory tube development|
|Fc-epsilon receptor signaling pathway|
|cellular response to interleukin-1|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to interleukin-1|
|endosome membrane|
|protein dephosphorylation|
|innate immune response-activating signal transduction|
|Fc receptor signaling pathway|
|heart morphogenesis|
|activation of innate immune response|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|protein-containing complex binding|
|protein deubiquitination|
|protein modification by small protein removal|
|dephosphorylation|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|in utero embryonic development|
|signal transduction by protein phosphorylation|
|nuclear speck|
|regulation of DNA-binding transcription factor activity|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|blood vessel development|
|cellular response to growth factor stimulus|
|positive regulation of multi-organism process|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|regulation of response to biotic stimulus|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|protein-containing complex|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of protein kinase activity|
|tube development|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|protein modification by small protein conjugation or removal|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|proteolysis|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8917
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAB1 Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>