TAC1 [The Human Chemical-Genetic Interaction Map Project]

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======= TAC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAC1
  * **<color #00a2e8>Official Name</color>**: tachykinin precursor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6863|6863]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20366|P20366]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162320|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of corticosterone secretion|
|positive regulation of saliva secretion|
|substance P receptor binding|
|regulation of corticosterone secretion|
|positive regulation of synaptic transmission, cholinergic|
|positive regulation of glucocorticoid secretion|
|regulation of synaptic transmission, cholinergic|
|regulation of saliva secretion|
|tachykinin receptor signaling pathway|
|positive regulation of corticosteroid hormone secretion|
|positive regulation of action potential|
|positive regulation of digestive system process|
|positive regulation of steroid hormone secretion|
|regulation of glucocorticoid secretion|
|negative regulation of heart rate|
|insemination|
|positive regulation of synaptic transmission, GABAergic|
|positive regulation of renal sodium excretion|
|copulation|
|regulation of corticosteroid hormone secretion|
|regulation of steroid hormone secretion|
|regulation of renal sodium excretion|
|regulation of excretion|
|negative regulation of heart contraction|
|positive regulation of acute inflammatory response|
|response to pain|
|regulation of synaptic transmission, GABAergic|
|long-term memory|
|mating|
|response to morphine|
|negative regulation of blood circulation|
|response to isoquinoline alkaloid|
|regulation of renal system process|
|regulation of digestive system process|
|regulation of endocrine process|
|regulation of acute inflammatory response|
|cellular response to nerve growth factor stimulus|
|regulation of action potential|
|positive regulation of stress fiber assembly|
|response to nerve growth factor|
|positive regulation of actin filament bundle assembly|
|positive regulation of lipid transport|
|multicellular organismal response to stress|
|sensory perception of pain|
|associative learning|
|response to anesthetic|
|regulation of stress fiber assembly|
|positive regulation of lipid localization|
|positive regulation of ossification|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|regulation of heart rate|
|neuropeptide signaling pathway|
|regulation of lipid transport|
|response to alkaloid|
|memory|
|detection of abiotic stimulus|
|positive regulation of hormone secretion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of lipid localization|
|positive regulation of inflammatory response|
|positive regulation of epithelial cell migration|
|learning|
|positive regulation of synaptic transmission|
|regulation of blood pressure|
|response to ammonium ion|
|regulation of ossification|
|positive regulation of supramolecular fiber organization|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|multi-multicellular organism process|
|regulation of epithelial cell migration|
|positive regulation of cytoskeleton organization|
|regulation of leukocyte proliferation|
|regulation of heart contraction|
|learning or memory|
|regulation of actin filament organization|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|axon|
|cognition|
|response to xenobiotic stimulus|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|regulation of inflammatory response|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|positive regulation of lymphocyte activation|
|neuronal cell body|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|positive regulation of defense response|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|inflammatory response|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|regulation of lymphocyte activation|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|behavior|
|regulation of system process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|response to bacterium|
|detection of stimulus|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of defense response|
|ion homeostasis|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|sensory perception|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.73|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17345
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAC1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>