TACR1 [The Human Chemical-Genetic Interaction Map Project]

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======= TACR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TACR1
  * **<color #00a2e8>Official Name</color>**: tachykinin receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6869|6869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25103|P25103]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TACR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TACR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162323|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|substance P receptor activity|
|tachykinin receptor activity|
|tachykinin receptor signaling pathway|
|sperm head|
|regulation of uterine smooth muscle contraction|
|positive regulation of flagellated sperm motility|
|positive regulation of cilium-dependent cell motility|
|regulation of flagellated sperm motility|
|sperm midpiece|
|regulation of cilium-dependent cell motility|
|response to pain|
|sperm flagellum|
|regulation of smooth muscle contraction|
|multicellular organismal response to stress|
|positive regulation of reproductive process|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|detection of abiotic stimulus|
|regulation of reproductive process|
|regulation of muscle contraction|
|regulation of muscle system process|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|inflammatory response|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|detection of stimulus|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|chemical homeostasis|
|response to abiotic stimulus|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14566
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TACR1 Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>