TACR2 [The Human Chemical-Genetic Interaction Map Project]

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======= TACR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TACR2
  * **<color #00a2e8>Official Name</color>**: tachykinin receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6865|6865]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21452|P21452]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TACR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TACR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162321|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. {ECO:0000269|PubMed:1659297}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|substance K receptor activity|
|positive regulation of acetylcholine secretion, neurotransmission|
|regulation of acetylcholine secretion, neurotransmission|
|negative regulation of luteinizing hormone secretion|
|tachykinin receptor activity|
|operant conditioning|
|intestine smooth muscle contraction|
|positive regulation of synaptic transmission, cholinergic|
|prolactin secretion|
|regulation of synaptic transmission, cholinergic|
|gastro-intestinal system smooth muscle contraction|
|negative regulation of gonadotropin secretion|
|positive regulation of uterine smooth muscle contraction|
|regulation of luteinizing hormone secretion|
|tachykinin receptor signaling pathway|
|sperm head|
|regulation of uterine smooth muscle contraction|
|positive regulation of vascular permeability|
|positive regulation of cilium-dependent cell motility|
|positive regulation of flagellated sperm motility|
|regulation of gonadotropin secretion|
|regulation of flagellated sperm motility|
|phasic smooth muscle contraction|
|positive regulation of neurotransmitter secretion|
|sperm midpiece|
|regulation of cilium-dependent cell motility|
|positive regulation of response to drug|
|positive regulation of smooth muscle contraction|
|positive regulation of amine transport|
|regulation of vascular permeability|
|positive regulation of neurotransmitter transport|
|excretion|
|response to electrical stimulus|
|sperm flagellum|
|regulation of endocrine process|
|positive regulation of muscle contraction|
|smooth muscle contraction|
|peptide hormone secretion|
|regulation of smooth muscle contraction|
|negative regulation of hormone secretion|
|hormone secretion|
|positive regulation of reproductive process|
|hormone transport|
|regulation of amine transport|
|regulation of response to drug|
|regulation of neurotransmitter secretion|
|regulation of neurotransmitter transport|
|learning|
|positive regulation of synaptic transmission|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of muscle contraction|
|regulation of reproductive process|
|protein localization to extracellular region|
|vascular process in circulatory system|
|signal release|
|peptide secretion|
|negative regulation of secretion by cell|
|negative regulation of secretion|
|regulation of muscle system process|
|muscle contraction|
|learning or memory|
|regulation of hormone secretion|
|positive regulation of ion transport|
|cognition|
|muscle system process|
|regulation of neurotransmitter levels|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of transport|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|behavior|
|regulation of system process|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3354
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TACR2 Expression in NALM6 Cells: 0.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>