TADA1 [The Human Chemical-Genetic Interaction Map Project]

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======= TADA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TADA1
  * **<color #00a2e8>Official Name</color>**: transcriptional adaptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=117143|117143]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BN2|Q96BN2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TADA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TADA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612763|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probably involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAGA-Tad1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|STAGA complex|
|SAGA complex|
|histone H3 acetylation|
|histone acetyltransferase activity|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|transcription coactivator activity|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|focal adhesion|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.27|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.05|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.02|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.93|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.87|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.83|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.81|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.78|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.73|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.71|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.74|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.75|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.76|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.88|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.68|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.05|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:taf6l|TAF6L]]|0.631|
|[[:human genes:s:supt7l|SUPT7L]]|0.625|
|[[:human genes:t:taf5l|TAF5L]]|0.625|
|[[:human genes:c:ccdc101|CCDC101]]|0.61|
|[[:human genes:t:tada2b|TADA2B]]|0.604|
|[[:human genes:s:supt20h|SUPT20H]]|0.547|
|[[:human genes:m:med13|MED13]]|0.535|
|[[:human genes:m:mllt1|MLLT1]]|0.524|
|[[:human genes:m:med23|MED23]]|0.515|
|[[:human genes:t:tada3|TADA3]]|0.496|
|[[:human genes:b:brpf1|BRPF1]]|0.475|
|[[:human genes:m:med16|MED16]]|0.473|
|[[:human genes:m:med18|MED18]]|0.464|
|[[:human genes:m:med13l|MED13L]]|0.454|
|[[:human genes:s:smarcd1|SMARCD1]]|0.439|
|[[:human genes:f:fli1|FLI1]]|0.434|
|[[:human genes:m:maml1|MAML1]]|0.432|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.428|
|[[:human genes:a:atf7ip|ATF7IP]]|0.425|
|[[:human genes:u:usp22|USP22]]|0.419|
|[[:human genes:t:tti2|TTI2]]|0.418|
|[[:human genes:t:thoc6|THOC6]]|0.417|
|[[:human genes:u:ube2l3|UBE2L3]]|0.416|
|[[:human genes:u:ube3a|UBE3A]]|0.415|
|[[:human genes:t:tceb3|TCEB3]]|0.415|
|[[:human genes:m:max|MAX]]|0.411|
|[[:human genes:g:gnb1l|GNB1L]]|0.406|
|[[:human genes:a:aars|AARS]]|0.403|
|[[:human genes:w:wdr24|WDR24]]|0.403|
|[[:human genes:m:mapk14|MAPK14]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|2/21|
|liver|3/20|
|lung|1/75|
|lymphocyte|3/14|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1953
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TADA1 Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>