TAF3 [The Human Chemical-Genetic Interaction Map Project]

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======= TAF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF3
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83860|83860]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5VWG9|Q5VWG9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606576|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|Bromo TP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of protein location in nucleus|
|transcription factor TFIID complex|
|maintenance of protein localization in organelle|
|p53 binding|
|maintenance of protein location in cell|
|maintenance of location in cell|
|maintenance of protein location|
|negative regulation of DNA-binding transcription factor activity|
|protein localization to nucleus|
|maintenance of location|
|transcription initiation from RNA polymerase II promoter|
|regulation of signal transduction by p53 class mediator|
|DNA-templated transcription, initiation|
|nuclear membrane|
|regulation of DNA-binding transcription factor activity|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|protein localization to organelle|
|negative regulation of transcription by RNA polymerase II|
|nucleobase-containing compound biosynthetic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|cellular macromolecule localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.53|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.75|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.73|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.74|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.83|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.01|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.02|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.1|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.19|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.22|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.53|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.65|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:taf4|TAF4]]|0.575|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 405
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF3 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>