TAF4 [The Human Chemical-Genetic Interaction Map Project]

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======= TAF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF4
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6874|6874]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00268|O00268]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601796|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TAF4|
|TAFH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aryl hydrocarbon receptor binding|
|transcription factor TFTC complex|
|MLL1 complex|
|transcription factor TFIID complex|
|ovarian follicle development|
|female gonad development|
|development of primary female sexual characteristics|
|female sex differentiation|
|transcription initiation from RNA polymerase II promoter|
|regulation of signal transduction by p53 class mediator|
|gonad development|
|development of primary sexual characteristics|
|DNA-templated transcription, initiation|
|nuclear chromatin|
|sex differentiation|
|transcription coactivator activity|
|transcription factor binding|
|reproductive structure development|
|reproductive system development|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|protein-containing complex|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.77|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.79|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.83|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.84|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.39|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.51|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|3.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:taf3|TAF3]]|0.575|
|[[:human genes:u:ube2g2|UBE2G2]]|0.477|
|[[:human genes:d:dohh|DOHH]]|0.474|
|[[:human genes:p:pdpk1|PDPK1]]|0.438|
|[[:human genes:t:trim28|TRIM28]]|0.415|
|[[:human genes:n:nsd1|NSD1]]|0.413|
|[[:human genes:f:faf2|FAF2]]|0.412|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.408|
|[[:human genes:p:plaa|PLAA]]|0.407|
|[[:human genes:m:mnat1|MNAT1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|2/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF4 Expression in NALM6 Cells: 5.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>