TAF5L [The Human Chemical-Genetic Interaction Map Project]

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======= TAF5L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF5L
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 5 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27097|27097]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75529|O75529]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF5L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF5L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIID 90kDa|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|STAGA complex|
|transcription factor TFTC complex|
|histone H3 acetylation|
|histone acetyltransferase activity|
|cytoplasmic ribonucleoprotein granule|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|transcription coactivator activity|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|nuclear speck|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.7|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.6|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.6|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.44|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.3|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.18|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.1|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.03|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.03|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.91|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.87|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.86|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.84|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.81|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.8|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.76|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.76|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.76|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.72|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.71|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.71|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.8|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.83|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.94|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.19|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.37|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.53|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.54|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|4.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt7l|SUPT7L]]|0.689|
|[[:human genes:t:tada2b|TADA2B]]|0.652|
|[[:human genes:t:taf6l|TAF6L]]|0.626|
|[[:human genes:t:tada1|TADA1]]|0.625|
|[[:human genes:c:ccdc101|CCDC101]]|0.622|
|[[:human genes:t:tada3|TADA3]]|0.588|
|[[:human genes:m:med13|MED13]]|0.569|
|[[:human genes:m:mllt1|MLLT1]]|0.561|
|[[:human genes:m:med13l|MED13L]]|0.535|
|[[:human genes:m:med23|MED23]]|0.522|
|[[:human genes:k:kat2a|KAT2A]]|0.521|
|[[:human genes:u:usp22|USP22]]|0.517|
|[[:human genes:b:brpf1|BRPF1]]|0.515|
|[[:human genes:m:maml1|MAML1]]|0.509|
|[[:human genes:s:supt20h|SUPT20H]]|0.479|
|[[:human genes:z:znf592|ZNF592]]|0.476|
|[[:human genes:i:id3|ID3]]|0.473|
|[[:human genes:f:fli1|FLI1]]|0.467|
|[[:human genes:a:aff1|AFF1]]|0.459|
|[[:human genes:t:tceb3|TCEB3]]|0.457|
|[[:human genes:m:med16|MED16]]|0.455|
|[[:human genes:a:atxn7|ATXN7]]|0.452|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.448|
|[[:human genes:m:mapk14|MAPK14]]|0.446|
|[[:human genes:d:ddx5|DDX5]]|0.435|
|[[:human genes:r:rptor|RPTOR]]|0.433|
|[[:human genes:a:atf7ip|ATF7IP]]|0.432|
|[[:human genes:e:ehmt2|EHMT2]]|0.425|
|[[:human genes:m:max|MAX]]|0.419|
|[[:human genes:u:ube3a|UBE3A]]|0.418|
|[[:human genes:h:hdac8|HDAC8]]|0.417|
|[[:human genes:d:dcaf5|DCAF5]]|0.417|
|[[:human genes:m:med25|MED25]]|0.414|
|[[:human genes:w:wdr24|WDR24]]|0.413|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.412|
|[[:human genes:s:ssbp2|SSBP2]]|0.408|
|[[:human genes:z:zmiz1|ZMIZ1]]|0.408|
|[[:human genes:s:setdb1|SETDB1]]|0.406|
|[[:human genes:f:fbxo11|FBXO11]]|0.405|
|[[:human genes:t:tle4|TLE4]]|0.403|
|[[:human genes:a:arih1|ARIH1]]|0.402|
|[[:human genes:t:trim33|TRIM33]]|0.402|
|[[:human genes:z:znf410|ZNF410]]|0.4|
|[[:human genes:t:tti1|TTI1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|2/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2191
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF5L Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>