TAF7 [The Human Chemical-Genetic Interaction Map Project]

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======= TAF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF7
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6879|6879]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15545|Q15545]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600573|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). {ECO:0000269|PubMed:10438527}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TAFII55 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spermine transport|
|P-TEFb complex binding|
|H3K27me3 modified histone binding|
|polyamine transport|
|TFIIH-class transcription factor complex binding|
|RNA polymerase II preinitiation complex assembly|
|transcription factor TFTC complex|
|vitamin D receptor binding|
|negative regulation of histone acetylation|
|negative regulation of peptidyl-lysine acetylation|
|intracellular estrogen receptor signaling pathway|
|negative regulation of protein acetylation|
|regulation of transcription initiation from RNA polymerase II promoter|
|histone acetyltransferase binding|
|transcription preinitiation complex assembly|
|thyroid hormone receptor binding|
|MLL1 complex|
|regulation of DNA-templated transcription, initiation|
|transcription factor TFIID complex|
|negative regulation of histone modification|
|ammonium transport|
|regulation of histone acetylation|
|negative regulation of chromatin organization|
|regulation of peptidyl-lysine acetylation|
|intracellular steroid hormone receptor signaling pathway|
|regulation of protein acetylation|
|steroid hormone mediated signaling pathway|
|negative regulation of chromosome organization|
|regulation of histone modification|
|drug transport|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|regulation of signal transduction by p53 class mediator|
|cellular response to steroid hormone stimulus|
|regulation of chromatin organization|
|protein-DNA complex assembly|
|transcription factor complex|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|negative regulation of protein kinase activity|
|protein-DNA complex subunit organization|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|transcription coactivator activity|
|response to steroid hormone|
|transcription factor binding|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of cellular component organization|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|cation transport|
|cellular protein-containing complex assembly|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|response to hormone|
|response to organic cyclic compound|
|regulation of transferase activity|
|Golgi apparatus|
|response to drug|
|negative regulation of cellular protein metabolic process|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of phosphorylation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.38|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.453|
|[[:human genes:p:polr2j3|POLR2J3]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 509/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|21/28|
|bone|19/25|
|breast|21/33|
|central nervous system|36/56|
|cervix|2/4|
|colorectal|12/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|13/15|
|kidney|16/21|
|liver|13/20|
|lung|49/75|
|lymphocyte|9/14|
|ovary|19/26|
|pancreas|15/24|
|peripheral nervous system|9/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|6/7|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|15/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1911
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF7 Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>