TAF9 [The Human Chemical-Genetic Interaction Map Project]

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======= TAF9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAF9
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein associated factor 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6880|6880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16594|Q16594]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAF9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAF9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600822|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TFIID-31kDa|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PCAF complex|
|pre-snoRNP complex|
|box C/D snoRNP assembly|
|small nucleolar ribonucleoprotein complex assembly|
|STAGA complex|
|transcription factor TFTC complex|
|C2H2 zinc finger domain binding|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|SAGA complex|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|MLL1 complex|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|negative regulation of signal transduction by p53 class mediator|
|activating transcription factor binding|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|transcription factor TFIID complex|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|histone H3 acetylation|
|negative regulation of ubiquitin-dependent protein catabolic process|
|histone acetyltransferase activity|
|positive regulation of response to cytokine stimulus|
|negative regulation of proteasomal protein catabolic process|
|p53 binding|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|ATPase binding|
|negative regulation of response to DNA damage stimulus|
|negative regulation of cellular protein catabolic process|
|ncRNA transcription|
|negative regulation of intrinsic apoptotic signaling pathway|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|protein acetylation|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of cell growth|
|regulation of response to cytokine stimulus|
|transcription initiation from RNA polymerase II promoter|
|protein stabilization|
|regulation of signal transduction by p53 class mediator|
|regulation of proteasomal protein catabolic process|
|protein acylation|
|response to interleukin-1|
|regulation of proteolysis involved in cellular protein catabolic process|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|positive regulation of growth|
|transcription coactivator activity|
|regulation of protein stability|
|negative regulation of catabolic process|
|peptidyl-lysine modification|
|transcription factor binding|
|negative regulation of proteolysis|
|histone modification|
|covalent chromatin modification|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|regulation of cell growth|
|ribonucleoprotein complex biogenesis|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|negative regulation of intracellular signal transduction|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of growth|
|chromatin organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|DNA binding|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.24|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.81|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5874
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAF9 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>