TARBP2 [The Human Chemical-Genetic Interaction Map Project]

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======= TARBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TARBP2
  * **<color #00a2e8>Official Name</color>**: TARBP2 subunit of RISC loading complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6895|6895]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15633|Q15633]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TARBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TARBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605053|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. {ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:12475984, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:19219043}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dsrm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of production of siRNA involved in RNA interference|
|negative regulation of defense response to virus by host|
|targeting of mRNA for destruction involved in RNA interference|
|siRNA loading onto RISC involved in RNA interference|
|regulation of RNA interference|
|pre-miRNA binding|
|miRNA loading onto RISC involved in gene silencing by miRNA|
|small RNA loading onto RISC|
|RISC-loading complex|
|production of siRNA involved in RNA interference|
|siRNA binding|
|pre-miRNA processing|
|pre-mRNA binding|
|RISC complex|
|RNA interference|
|regulation of production of miRNAs involved in gene silencing by miRNA|
|regulation of production of small RNA involved in gene silencing by RNA|
|miRNA metabolic process|
|negative regulation of defense response to virus|
|production of miRNAs involved in gene silencing by miRNA|
|miRNA binding|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|skeletal muscle tissue regeneration|
|positive regulation of viral genome replication|
|regulation of defense response to virus by host|
|gene silencing by miRNA|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|positive regulation of viral life cycle|
|tissue regeneration|
|regulation of viral transcription|
|double-stranded RNA binding|
|regulation of defense response to virus|
|neural precursor cell proliferation|
|multicellular organism growth|
|positive regulation of muscle cell differentiation|
|regulation of gene silencing by miRNA|
|gene silencing by RNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|negative regulation of response to biotic stimulus|
|regulation of viral genome replication|
|protein N-terminus binding|
|positive regulation of viral process|
|negative regulation of immune effector process|
|positive regulation of translation|
|regulation of gene silencing|
|single fertilization|
|regulation of viral life cycle|
|spermatid development|
|positive regulation of cellular amide metabolic process|
|gene silencing|
|regulation of muscle cell differentiation|
|spermatid differentiation|
|regeneration|
|fertilization|
|regulation of viral process|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of protein kinase activity|
|ribonucleoprotein complex assembly|
|regulation of gene expression, epigenetic|
|ribonucleoprotein complex subunit organization|
|negative regulation of kinase activity|
|germ cell development|
|negative regulation of transferase activity|
|nuclear body|
|enzyme binding|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of response to external stimulus|
|ncRNA processing|
|developmental growth|
|growth|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|ribonucleoprotein complex biogenesis|
|regulation of immune effector process|
|ncRNA metabolic process|
|wound healing|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|response to wounding|
|negative regulation of protein modification process|
|developmental process involved in reproduction|
|gamete generation|
|perinuclear region of cytoplasm|
|regulation of defense response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|regulation of kinase activity|
|RNA processing|
|protein homodimerization activity|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|multi-organism reproductive process|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.14|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.78|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.76|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6446
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TARBP2 Expression in NALM6 Cells: 4.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>