TAS2R43 [The Human Chemical-Genetic Interaction Map Project]

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======= TAS2R43 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAS2R43
  * **<color #00a2e8>Official Name</color>**: taste 2 receptor member 43
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=259289|259289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P59537|P59537]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAS2R43&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAS2R43|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612668|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. Activated by the sulfonyl amide sweeteners saccharin and acesulfame K. In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. May act as chemosensory receptors in airway epithelial cells to detect and eliminate potential noxious agents from the airways (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TAS2R|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|taste receptor activity|
|bitter taste receptor activity|
|detection of chemical stimulus involved in sensory perception of bitter taste|
|sensory perception of bitter taste|
|detection of chemical stimulus involved in sensory perception of taste|
|ciliary membrane|
|sensory perception of taste|
|motile cilium|
|detection of chemical stimulus involved in sensory perception|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|detection of stimulus|
|G protein-coupled receptor activity|
|sensory perception|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.94|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.92|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.85|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.81|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.94|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.96|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.12|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8314
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAS2R43 Expression in NALM6 Cells: -0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>