TAS2R46 [The Human Chemical-Genetic Interaction Map Project]

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======= TAS2R46 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TAS2R46
  * **<color #00a2e8>Official Name</color>**: taste 2 receptor member 46
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=259292|259292]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P59540|P59540]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TAS2R46&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TAS2R46|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TAS2R|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bitter taste receptor activity|
|detection of chemical stimulus involved in sensory perception of bitter taste|
|sensory perception of bitter taste|
|detection of chemical stimulus involved in sensory perception of taste|
|ciliary membrane|
|sensory perception of taste|
|detection of chemical stimulus involved in sensory perception|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|detection of stimulus|
|G protein-coupled receptor activity|
|sensory perception|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.09|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.85|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.76|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.75|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.74|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5381
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TAS2R46 Expression in NALM6 Cells: -1.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>