TBC1D25 [The Human Chemical-Genetic Interaction Map Project]

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======= TBC1D25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBC1D25
  * **<color #00a2e8>Official Name</color>**: TBC1 domain family member 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4943|4943]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3MII6|Q3MII6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBC1D25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBC1D25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/311240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. {ECO:0000269|PubMed:21383079}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of autophagosome maturation|
|autophagosome|
|activation of GTPase activity|
|regulation of protein complex disassembly|
|Rab GTPase binding|
|regulation of macroautophagy|
|cytoplasmic vesicle|
|process utilizing autophagic mechanism|
|autophagy|
|GTPase activator activity|
|regulation of autophagy|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|intracellular protein transport|
|regulation of catabolic process|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12743
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBC1D25 Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>