TBCB [The Human Chemical-Genetic Interaction Map Project]

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======= TBCB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBCB
  * **<color #00a2e8>Official Name</color>**: tubulin folding cofactor B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1155|1155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99426|Q99426]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBCB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBCB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601303|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAP GLY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule cytoskeleton|
|microtubule|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg1|ALG1]]|0.553|
|[[:human genes:g:gemin7|GEMIN7]]|0.544|
|[[:human genes:g:gemin8|GEMIN8]]|0.542|
|[[:human genes:t:thg1l|THG1L]]|0.539|
|[[:human genes:v:vezt|VEZT]]|0.522|
|[[:human genes:r:rpp21|RPP21]]|0.522|
|[[:human genes:d:dohh|DOHH]]|0.489|
|[[:human genes:t:ten1|TEN1]]|0.488|
|[[:human genes:u:uap1|UAP1]]|0.488|
|[[:human genes:c:c15orf41|C15orf41]]|0.487|
|[[:human genes:r:rft1|RFT1]]|0.485|
|[[:human genes:r:rpia|RPIA]]|0.481|
|[[:human genes:r:rtcb|RTCB]]|0.48|
|[[:human genes:t:tsen54|TSEN54]]|0.479|
|[[:human genes:d:dpagt1|DPAGT1]]|0.478|
|[[:human genes:a:atxn10|ATXN10]]|0.477|
|[[:human genes:l:lsm10|LSM10]]|0.477|
|[[:human genes:t:tti2|TTI2]]|0.472|
|[[:human genes:p:pmm2|PMM2]]|0.47|
|[[:human genes:r:rptor|RPTOR]]|0.467|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.467|
|[[:human genes:t:ttc4|TTC4]]|0.46|
|[[:human genes:u:uhrf1|UHRF1]]|0.457|
|[[:human genes:d:dr1|DR1]]|0.455|
|[[:human genes:g:gfpt1|GFPT1]]|0.455|
|[[:human genes:c:ctc1|CTC1]]|0.454|
|[[:human genes:p:ppp4c|PPP4C]]|0.453|
|[[:human genes:p:pdcd5|PDCD5]]|0.453|
|[[:human genes:t:triap1|TRIAP1]]|0.451|
|[[:human genes:d:ddx55|DDX55]]|0.449|
|[[:human genes:g:gnb1l|GNB1L]]|0.449|
|[[:human genes:t:tsen34|TSEN34]]|0.447|
|[[:human genes:d:ddx20|DDX20]]|0.444|
|[[:human genes:s:srd5a3|SRD5A3]]|0.444|
|[[:human genes:g:gmppb|GMPPB]]|0.444|
|[[:human genes:r:rabggtb|RABGGTB]]|0.442|
|[[:human genes:t:telo2|TELO2]]|0.438|
|[[:human genes:p:ppp6c|PPP6C]]|0.434|
|[[:human genes:e:exoc4|EXOC4]]|0.434|
|[[:human genes:w:wdr1|WDR1]]|0.429|
|[[:human genes:s:srp14|SRP14]]|0.429|
|[[:human genes:u:uxt|UXT]]|0.428|
|[[:human genes:d:dctn6|DCTN6]]|0.427|
|[[:human genes:g:gemin6|GEMIN6]]|0.427|
|[[:human genes:d:ddx1|DDX1]]|0.426|
|[[:human genes:z:zrsr2|ZRSR2]]|0.425|
|[[:human genes:s:snapc5|SNAPC5]]|0.424|
|[[:human genes:a:alg13|ALG13]]|0.424|
|[[:human genes:m:med16|MED16]]|0.424|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.422|
|[[:human genes:t:tti1|TTI1]]|0.419|
|[[:human genes:c:ccdc101|CCDC101]]|0.414|
|[[:human genes:d:dolk|DOLK]]|0.413|
|[[:human genes:f:fh|FH]]|0.412|
|[[:human genes:r:rfk|RFK]]|0.411|
|[[:human genes:r:rnmt|RNMT]]|0.411|
|[[:human genes:g:gclc|GCLC]]|0.41|
|[[:human genes:a:alg2|ALG2]]|0.409|
|[[:human genes:a:adsl|ADSL]]|0.409|
|[[:human genes:e:elp3|ELP3]]|0.409|
|[[:human genes:n:nae1|NAE1]]|0.408|
|[[:human genes:p:ppcs|PPCS]]|0.407|
|[[:human genes:d:dhrsx|DHRSX]]|0.406|
|[[:human genes:w:wdr59|WDR59]]|0.405|
|[[:human genes:m:msto1|MSTO1]]|0.404|
|[[:human genes:f:fntb|FNTB]]|0.403|
|[[:human genes:e:eef1e1|EEF1E1]]|0.401|
|[[:human genes:s:slc25a19|SLC25A19]]|0.4|
|[[:human genes:t:trmt10a|TRMT10A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 714/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|30/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|19/21|
|liver|20/20|
|lung|70/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1137
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBCB Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>