TBP [The Human Chemical-Genetic Interaction Map Project]

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======= TBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBP
  * **<color #00a2e8>Official Name</color>**: TATA-box binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6908|6908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20226|P20226]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600075|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:2194289, ECO:0000269|PubMed:2363050, ECO:0000269|PubMed:2374612, ECO:0000269|PubMed:26638071, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:9836642, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TFIIB-class transcription factor binding|
|RNA polymerase III regulatory region DNA binding|
|RNA polymerase III general transcription initiation factor activity|
|transcription factor TFIIA complex|
|transcription factor TFIIIB complex|
|male pronucleus|
|transcriptional preinitiation complex|
|RNA polymerase III preinitiation complex assembly|
|aryl hydrocarbon receptor binding|
|female pronucleus|
|transcription initiation from RNA polymerase III promoter|
|core promoter binding|
|RNA polymerase II general transcription initiation factor activity|
|RNA polymerase II preinitiation complex assembly|
|transcription preinitiation complex assembly|
|transcription elongation from RNA polymerase I promoter|
|nuclear euchromatin|
|termination of RNA polymerase I transcription|
|proximal promoter sequence-specific DNA binding|
|RNA polymerase II core promoter sequence-specific DNA binding|
|RNA polymerase II repressing transcription factor binding|
|transcription initiation from RNA polymerase I promoter|
|transcription factor TFIID complex|
|transcription by RNA polymerase I|
|repressing transcription factor binding|
|transcription by RNA polymerase III|
|positive regulation of gene expression, epigenetic|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|DNA-templated transcription, termination|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|transcription initiation from RNA polymerase II promoter|
|regulation of signal transduction by p53 class mediator|
|protein-DNA complex assembly|
|transcription factor complex|
|DNA-templated transcription, initiation|
|transcription regulatory region DNA binding|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|protein-DNA complex subunit organization|
|transcription factor binding|
|enzyme binding|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|spermatogenesis|
|male gamete generation|
|protein-containing complex|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|gamete generation|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|multi-organism reproductive process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.85|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.71|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.74|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.78|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.08|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.22|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.23|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.32|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.4|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rptor|RPTOR]]|0.539|
|[[:human genes:p:polr3h|POLR3H]]|0.511|
|[[:human genes:g:gfpt1|GFPT1]]|0.503|
|[[:human genes:w:wdr24|WDR24]]|0.492|
|[[:human genes:d:dohh|DOHH]]|0.485|
|[[:human genes:d:dpagt1|DPAGT1]]|0.479|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.479|
|[[:human genes:m:mars|MARS]]|0.477|
|[[:human genes:m:mios|MIOS]]|0.475|
|[[:human genes:h:hars|HARS]]|0.474|
|[[:human genes:m:mtor|MTOR]]|0.471|
|[[:human genes:t:thg1l|THG1L]]|0.47|
|[[:human genes:e:eny2|ENY2]]|0.469|
|[[:human genes:a:alg1|ALG1]]|0.469|
|[[:human genes:a:aars|AARS]]|0.468|
|[[:human genes:g:gmppb|GMPPB]]|0.462|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.46|
|[[:human genes:p:pmm2|PMM2]]|0.455|
|[[:human genes:r:rnmt|RNMT]]|0.453|
|[[:human genes:w:wdr59|WDR59]]|0.444|
|[[:human genes:u:uap1|UAP1]]|0.443|
|[[:human genes:g:gtf3a|GTF3A]]|0.436|
|[[:human genes:r:rtcb|RTCB]]|0.436|
|[[:human genes:t:triap1|TRIAP1]]|0.434|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.432|
|[[:human genes:s:srp14|SRP14]]|0.431|
|[[:human genes:s:srp68|SRP68]]|0.427|
|[[:human genes:a:alg13|ALG13]]|0.426|
|[[:human genes:m:mapk14|MAPK14]]|0.422|
|[[:human genes:a:alg5|ALG5]]|0.422|
|[[:human genes:e:eno1|ENO1]]|0.415|
|[[:human genes:n:nup50|NUP50]]|0.414|
|[[:human genes:n:nae1|NAE1]]|0.413|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.413|
|[[:human genes:p:polr3b|POLR3B]]|0.412|
|[[:human genes:m:meaf6|MEAF6]]|0.411|
|[[:human genes:v:vps41|VPS41]]|0.411|
|[[:human genes:c:casp9|CASP9]]|0.408|
|[[:human genes:a:atxn10|ATXN10]]|0.408|
|[[:human genes:t:thoc6|THOC6]]|0.403|
|[[:human genes:n:nxt1|NXT1]]|0.403|
|[[:human genes:m:mis18a|MIS18A]]|0.403|
|[[:human genes:b:b3gnt2|B3GNT2]]|0.402|
|[[:human genes:e:eif4e|EIF4E]]|0.401|
|[[:human genes:c:csnk2b|CSNK2B]]|0.401|
|[[:human genes:s:srp72|SRP72]]|0.4|
|[[:human genes:a:atp5j|ATP5J]]|0.4|
|[[:human genes:o:oraov1|ORAOV1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/14|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1742
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBP Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>