TBX2 [The Human Chemical-Genetic Interaction Map Project]

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======= TBX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TBX2
  * **<color #00a2e8>Official Name</color>**: T-box transcription factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6909|6909]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13207|Q13207]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TBX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TBX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600747|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation. {ECO:0000269|PubMed:22002537}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TBX|
|T-box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cardiac chamber morphogenesis|
|negative regulation of cardiac chamber morphogenesis|
|regulation of cardiac chamber formation|
|negative regulation of cardiac chamber formation|
|negative regulation of heart looping|
|regulation of heart looping|
|muscle cell fate determination|
|mammary placode formation|
|pharynx development|
|mammary gland formation|
|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|
|atrioventricular canal development|
|cardiac muscle cell myoblast differentiation|
|ectodermal placode formation|
|ectodermal placode morphogenesis|
|ectodermal placode development|
|cardioblast differentiation|
|regulation of transcription from RNA polymerase II promoter involved in heart development|
|muscle cell fate commitment|
|negative regulation of morphogenesis of an epithelium|
|positive regulation of cardiac muscle cell proliferation|
|negative regulation of embryonic development|
|embryonic camera-type eye morphogenesis|
|outflow tract septum morphogenesis|
|aorta morphogenesis|
|cellular senescence|
|positive regulation of cardiac muscle tissue growth|
|negative regulation of animal organ morphogenesis|
|embryonic eye morphogenesis|
|myoblast differentiation|
|endocardial cushion morphogenesis|
|positive regulation of heart growth|
|embryonic camera-type eye development|
|cell fate determination|
|regulation of heart morphogenesis|
|regulation of cardiac muscle cell proliferation|
|endocardial cushion development|
|mammary gland morphogenesis|
|positive regulation of cardiac muscle tissue development|
|positive regulation of organ growth|
|mesenchyme morphogenesis|
|aorta development|
|RNA polymerase II activating transcription factor binding|
|regulation of cardiac muscle tissue growth|
|heart looping|
|artery morphogenesis|
|embryonic digit morphogenesis|
|cell aging|
|regulation of heart growth|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|embryonic heart tube development|
|regulation of cardiac muscle tissue development|
|artery development|
|cell fate specification|
|roof of mouth development|
|regulation of organ growth|
|gland morphogenesis|
|cardiac septum development|
|camera-type eye morphogenesis|
|developmental growth involved in morphogenesis|
|cardiocyte differentiation|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|embryonic limb morphogenesis|
|Notch signaling pathway|
|embryonic appendage morphogenesis|
|cardiac chamber morphogenesis|
|mammary gland development|
|regulation of embryonic development|
|digestive tract development|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|digestive system development|
|eye morphogenesis|
|appendage morphogenesis|
|limb morphogenesis|
|stem cell differentiation|
|cardiac muscle tissue development|
|cardiac chamber development|
|positive regulation of developmental growth|
|appendage development|
|regulation of morphogenesis of an epithelium|
|limb development|
|transcription factor complex|
|mesenchyme development|
|regulation of heart contraction|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|aging|
|striated muscle tissue development|
|regulation of blood circulation|
|embryonic organ morphogenesis|
|muscle tissue development|
|epithelial tube morphogenesis|
|camera-type eye development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of developmental growth|
|eye development|
|visual system development|
|sensory system development|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|gland development|
|sequence-specific DNA binding|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|heart development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of system process|
|tube morphogenesis|
|regulation of growth|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.81|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.74|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.7|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.74|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7265
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TBX2 Expression in NALM6 Cells: 0.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>