TCEAL4 [The Human Chemical-Genetic Interaction Map Project]

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======= TCEAL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCEAL4
  * **<color #00a2e8>Official Name</color>**: transcription elongation factor A like 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79921|79921]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EI5|Q96EI5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCEAL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCEAL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301154|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BEX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|WW domain binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.04|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.99|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.96|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.87|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.78|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.78|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.7|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.71|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6173
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCEAL4 Expression in NALM6 Cells: -0.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>