TCF7 [The Human Chemical-Genetic Interaction Map Project]

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======= TCF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TCF7
  * **<color #00a2e8>Official Name</color>**: transcription factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6932|6932]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36402|P36402]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TCF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TCF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189908|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
|CTNNB1 binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic genitalia morphogenesis|
|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|
|embryonic hindgut morphogenesis|
|somatic diversification of T cell receptor genes|
|T cell receptor V(D)J recombination|
|somatic recombination of T cell receptor gene segments|
|hindgut morphogenesis|
|hindgut development|
|genitalia morphogenesis|
|V(D)J recombination|
|embryonic digestive tract morphogenesis|
|cellular response to interleukin-4|
|beta-catenin-TCF complex assembly|
|nuclear euchromatin|
|response to interleukin-4|
|embryonic digestive tract development|
|somatic cell DNA recombination|
|somatic diversification of immune receptors via germline recombination within a single locus|
|genitalia development|
|digestive tract morphogenesis|
|somatic diversification of immune receptors|
|alpha-beta T cell differentiation|
|alpha-beta T cell activation|
|beta-catenin binding|
|canonical Wnt signaling pathway|
|digestive tract development|
|T cell differentiation|
|digestive system development|
|neural tube development|
|transcription factor complex|
|transcription regulatory region DNA binding|
|DNA recombination|
|T cell activation|
|lymphocyte differentiation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|sex differentiation|
|nuclear body|
|embryonic organ morphogenesis|
|leukocyte differentiation|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|lymphocyte activation|
|sequence-specific DNA binding|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|embryonic organ development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|hemopoiesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|DNA metabolic process|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|leukocyte activation|
|animal organ morphogenesis|
|embryo development|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|cell activation|
|response to cytokine|
|epithelium development|
|cell-cell signaling|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|negative regulation of gene expression|
|tissue development|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TCF7 Expression in NALM6 Cells: 2.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>