TDRD7 [The Human Chemical-Genetic Interaction Map Project]

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======= TDRD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TDRD7
  * **<color #00a2e8>Official Name</color>**: tudor domain containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23424|23424]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NHU6|Q8NHU6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TDRD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TDRD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611258|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated with cataract formation in mouse and human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TUDOR|
|OST LOTUS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonucleoprotein granule|
|chromatoid body|
|lens morphogenesis in camera-type eye|
|lens fiber cell differentiation|
|lens development in camera-type eye|
|protein N-terminus binding|
|camera-type eye morphogenesis|
|eye morphogenesis|
|mRNA binding|
|sensory organ morphogenesis|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|mitochondrial matrix|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|sensory organ development|
|male gamete generation|
|epithelial cell differentiation|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|animal organ morphogenesis|
|multi-organism reproductive process|
|epithelium development|
|reproductive process|
|reproduction|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.86|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17213
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TDRD7 Expression in NALM6 Cells: 4.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>