TELO2 [The Human Chemical-Genetic Interaction Map Project]

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======= TELO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TELO2
  * **<color #00a2e8>Official Name</color>**: telomere maintenance 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9894|9894]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4R8|Q9Y4R8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TELO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TELO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611140|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. {ECO:0000269|PubMed:12670948, ECO:0000269|PubMed:20810650}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Telomere reg-2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of TORC2 signaling|
|regulation of TORC2 signaling|
|ASTRA complex|
|TORC1 complex|
|TORC2 complex|
|nuclear periphery|
|positive regulation of TORC1 signaling|
|telomere maintenance via telomerase|
|telomeric DNA binding|
|telomere maintenance via telomere lengthening|
|RNA-dependent DNA biosynthetic process|
|positive regulation of TOR signaling|
|regulation of TORC1 signaling|
|Hsp90 protein binding|
|molecular adaptor activity|
|intracellular|
|telomere maintenance|
|telomere organization|
|regulation of TOR signaling|
|DNA biosynthetic process|
|nuclear chromosome, telomeric region|
|protein stabilization|
|protein-containing complex binding|
|nuclear body|
|regulation of protein stability|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|protein kinase binding|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|DNA metabolic process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.94|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.78|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.74|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.72|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.71|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.95|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.01|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.06|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.21|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.36|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|3.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gnb1l|GNB1L]]|0.657|
|[[:human genes:t:tti2|TTI2]]|0.654|
|[[:human genes:t:tti1|TTI1]]|0.612|
|[[:human genes:m:med16|MED16]]|0.598|
|[[:human genes:g:gmppb|GMPPB]]|0.59|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.583|
|[[:human genes:r:rpp21|RPP21]]|0.546|
|[[:human genes:r:rtcb|RTCB]]|0.54|
|[[:human genes:a:aars|AARS]]|0.534|
|[[:human genes:a:adsl|ADSL]]|0.534|
|[[:human genes:t:thg1l|THG1L]]|0.532|
|[[:human genes:r:rptor|RPTOR]]|0.532|
|[[:human genes:c:cct7|CCT7]]|0.531|
|[[:human genes:r:rnmt|RNMT]]|0.525|
|[[:human genes:d:dpagt1|DPAGT1]]|0.521|
|[[:human genes:u:uxt|UXT]]|0.516|
|[[:human genes:a:alg1|ALG1]]|0.515|
|[[:human genes:p:pmm2|PMM2]]|0.515|
|[[:human genes:t:thoc3|THOC3]]|0.505|
|[[:human genes:t:tsen54|TSEN54]]|0.504|
|[[:human genes:g:gfpt1|GFPT1]]|0.503|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.501|
|[[:human genes:c:ccdc101|CCDC101]]|0.497|
|[[:human genes:u:uap1|UAP1]]|0.492|
|[[:human genes:y:yars|YARS]]|0.49|
|[[:human genes:m:med23|MED23]]|0.489|
|[[:human genes:n:nars|NARS]]|0.488|
|[[:human genes:a:atxn10|ATXN10]]|0.487|
|[[:human genes:p:ppp4c|PPP4C]]|0.485|
|[[:human genes:d:dad1|DAD1]]|0.481|
|[[:human genes:p:polr3h|POLR3H]]|0.478|
|[[:human genes:m:mapk14|MAPK14]]|0.477|
|[[:human genes:a:alg13|ALG13]]|0.476|
|[[:human genes:c:cbfb|CBFB]]|0.475|
|[[:human genes:a:alg2|ALG2]]|0.475|
|[[:human genes:c:csnk2b|CSNK2B]]|0.474|
|[[:human genes:t:trnt1|TRNT1]]|0.474|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.472|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.471|
|[[:human genes:s:seh1l|SEH1L]]|0.471|
|[[:human genes:v:vezt|VEZT]]|0.468|
|[[:human genes:d:ddx20|DDX20]]|0.467|
|[[:human genes:s:srp68|SRP68]]|0.467|
|[[:human genes:v:vrk1|VRK1]]|0.466|
|[[:human genes:t:triap1|TRIAP1]]|0.466|
|[[:human genes:t:trmt5|TRMT5]]|0.463|
|[[:human genes:f:fnta|FNTA]]|0.462|
|[[:human genes:g:gpn2|GPN2]]|0.459|
|[[:human genes:n:nae1|NAE1]]|0.459|
|[[:human genes:h:haus8|HAUS8]]|0.459|
|[[:human genes:r:rpn1|RPN1]]|0.458|
|[[:human genes:w:wdr24|WDR24]]|0.457|
|[[:human genes:u:uhrf1|UHRF1]]|0.456|
|[[:human genes:e:exoc4|EXOC4]]|0.45|
|[[:human genes:p:pax5|PAX5]]|0.445|
|[[:human genes:m:mars|MARS]]|0.445|
|[[:human genes:s:snf8|SNF8]]|0.442|
|[[:human genes:m:mtor|MTOR]]|0.442|
|[[:human genes:z:znf259|ZNF259]]|0.441|
|[[:human genes:r:rbmx2|RBMX2]]|0.44|
|[[:human genes:e:eprs|EPRS]]|0.44|
|[[:human genes:h:hspd1|HSPD1]]|0.438|
|[[:human genes:t:tbcb|TBCB]]|0.438|
|[[:human genes:m:mllt1|MLLT1]]|0.436|
|[[:human genes:s:slc35b1|SLC35B1]]|0.436|
|[[:human genes:o:otud5|OTUD5]]|0.434|
|[[:human genes:o:osgep|OSGEP]]|0.433|
|[[:human genes:g:gemin5|GEMIN5]]|0.433|
|[[:human genes:o:oip5|OIP5]]|0.43|
|[[:human genes:s:srp14|SRP14]]|0.429|
|[[:human genes:e:ercc2|ERCC2]]|0.429|
|[[:human genes:e:elac2|ELAC2]]|0.429|
|[[:human genes:s:srp72|SRP72]]|0.426|
|[[:human genes:e:eif3f|EIF3F]]|0.425|
|[[:human genes:n:nsmce1|NSMCE1]]|0.421|
|[[:human genes:a:alg14|ALG14]]|0.419|
|[[:human genes:d:dohh|DOHH]]|0.417|
|[[:human genes:s:slc25a19|SLC25A19]]|0.417|
|[[:human genes:s:snapc5|SNAPC5]]|0.417|
|[[:human genes:t:tbcd|TBCD]]|0.417|
|[[:human genes:p:pelo|PELO]]|0.416|
|[[:human genes:d:dr1|DR1]]|0.416|
|[[:human genes:z:zbtb11|ZBTB11]]|0.416|
|[[:human genes:v:vmp1|VMP1]]|0.415|
|[[:human genes:t:thoc6|THOC6]]|0.415|
|[[:human genes:t:trip12|TRIP12]]|0.414|
|[[:human genes:w:wdr59|WDR59]]|0.414|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.41|
|[[:human genes:u:utp23|UTP23]]|0.407|
|[[:human genes:w:wdr82|WDR82]]|0.405|
|[[:human genes:d:dicer1|DICER1]]|0.405|
|[[:human genes:g:gemin8|GEMIN8]]|0.405|
|[[:human genes:a:actr10|ACTR10]]|0.404|
|[[:human genes:z:zrsr2|ZRSR2]]|0.403|
|[[:human genes:s:sec61g|SEC61G]]|0.403|
|[[:human genes:t:tle4|TLE4]]|0.402|
|[[:human genes:s:srprb|SRPRB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 178/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|4/28|
|bone|9/26|
|breast|8/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|5/21|
|liver|9/20|
|lung|18/75|
|lymphocyte|1/16|
|ovary|7/26|
|pancreas|8/24|
|peripheral nervous system|5/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 165
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TELO2 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>