TENC1 [The Human Chemical-Genetic Interaction Map Project]

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======= TENC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNS2
  * **<color #00a2e8>Official Name</color>**: tensin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23371|23371]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q63HR2|Q63HR2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TENC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TENC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607717|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PTEN C2|
|PTB|
|C1 1|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to muscle activity|
|phosphoprotein phosphatase activity|
|collagen metabolic process|
|response to activity|
|multicellular organism growth|
|kinase binding|
|protein dephosphorylation|
|kidney development|
|renal system development|
|dephosphorylation|
|urogenital system development|
|multicellular organismal homeostasis|
|developmental growth|
|growth|
|focal adhesion|
|negative regulation of cell population proliferation|
|cellular homeostasis|
|regulation of cell population proliferation|
|homeostatic process|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.83|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.77|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.72|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.7|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.7|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.7|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.77|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.79|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.48|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6930
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TENC1 Expression in NALM6 Cells: 1.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>