TENM1 [The Human Chemical-Genetic Interaction Map Project]

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======= TENM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TENM1
  * **<color #00a2e8>Official Name</color>**: teneurin transmembrane protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10178|10178]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKZ4|Q9UKZ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TENM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TENM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300588|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). {ECO:0000250}. Ten-1 intracellular domain: Induces gene transcription activation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ten N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcription by RNA polymerase III|
|positive regulation of filopodium assembly|
|regulation of filopodium assembly|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|cell adhesion molecule binding|
|positive regulation of actin filament polymerization|
|positive regulation of plasma membrane bounded cell projection assembly|
|positive regulation of peptidyl-serine phosphorylation|
|neuropeptide signaling pathway|
|nuclear matrix|
|positive regulation of protein polymerization|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of intracellular protein transport|
|regulation of actin filament polymerization|
|heparin binding|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of intracellular transport|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|regulation of intracellular protein transport|
|positive regulation of protein complex assembly|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|regulation of actin filament organization|
|positive regulation of MAP kinase activity|
|neuron projection|
|positive regulation of cellular protein localization|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|nuclear speck|
|positive regulation of protein transport|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|protein heterodimerization activity|
|cell-cell adhesion|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|neuron development|
|regulation of kinase activity|
|protein homodimerization activity|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|Golgi apparatus|
|positive regulation of transport|
|endoplasmic reticulum|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.83|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8719
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TENM1 Expression in NALM6 Cells: 1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>