TENM3 [The Human Chemical-Genetic Interaction Map Project]

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======= TENM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TENM3
  * **<color #00a2e8>Official Name</color>**: teneurin transmembrane protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55714|55714]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P273|Q9P273]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TENM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TENM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610083|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ten N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of homophilic cell adhesion|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|cell adhesion molecule binding|
|camera-type eye morphogenesis|
|eye morphogenesis|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|sensory organ morphogenesis|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|positive regulation of neuron projection development|
|axon|
|camera-type eye development|
|neuron projection|
|eye development|
|visual system development|
|positive regulation of neuron differentiation|
|sensory system development|
|positive regulation of cell projection organization|
|regulation of cell-cell adhesion|
|positive regulation of neurogenesis|
|protein heterodimerization activity|
|regulation of neuron projection development|
|cell-cell adhesion|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|neuron development|
|regulation of neurogenesis|
|protein homodimerization activity|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|neuron differentiation|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15427
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TENM3 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>