TEX14 [The Human Chemical-Genetic Interaction Map Project]

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======= TEX14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TEX14
  * **<color #00a2e8>Official Name</color>**: testis expressed 14, intercellular bridge forming factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56155|56155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWB6|Q8IWB6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TEX14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TEX14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605792|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Ank 2|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intercellular bridge organization|
|mitotic sister chromatid separation|
|negative regulation of cytokinesis|
|negative regulation of cell division|
|attachment of spindle microtubules to kinetochore|
|mitotic spindle checkpoint|
|spindle assembly checkpoint|
|spindle checkpoint|
|mitotic spindle assembly checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of mitotic sister chromatid segregation|
|chromosome separation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|male meiotic nuclear division|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|intercellular bridge|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|cell|
|kinetochore|
|regulation of cytokinesis|
|condensed chromosome kinetochore|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|regulation of chromosome segregation|
|negative regulation of protein binding|
|mitotic sister chromatid segregation|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|mitotic cell cycle checkpoint|
|midbody|
|meiotic cell cycle process|
|regulation of cell division|
|regulation of mitotic nuclear division|
|negative regulation of binding|
|regulation of nuclear division|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|regulation of protein binding|
|meiotic cell cycle|
|negative regulation of cell cycle phase transition|
|protein kinase activity|
|chromosome segregation|
|nuclear division|
|negative regulation of mitotic cell cycle|
|organelle fission|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of organelle organization|
|regulation of binding|
|extracellular structure organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|protein kinase binding|
|cell division|
|male gamete generation|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|gamete generation|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein phosphorylation|
|multi-organism reproductive process|
|cell cycle process|
|cellular response to cytokine stimulus|
|chromosome organization|
|response to cytokine|
|negative regulation of molecular function|
|regulation of cell cycle|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5781
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TEX14 Expression in NALM6 Cells: 1.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>