TEX40 [The Human Chemical-Genetic Interaction Map Project]

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======= TEX40 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CATSPERZ
  * **<color #00a2e8>Official Name</color>**: catsper channel auxiliary subunit zeta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25858|25858]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NTU4|Q9NTU4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TEX40&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TEX40|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617511|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. {ECO:0000250|UniProtKB:Q9CQP8}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CatSper complex|
|sperm principal piece|
|sperm capacitation|
|male meiotic nuclear division|
|flagellated sperm motility|
|sperm motility|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|spermatid development|
|meiotic nuclear division|
|spermatid differentiation|
|cell maturation|
|meiotic cell cycle process|
|meiotic cell cycle|
|developmental maturation|
|germ cell development|
|nuclear division|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|cell motility|
|localization of cell|
|locomotion|
|cell cycle|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6715
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TEX40 Expression in NALM6 Cells: -1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>