TFAM [The Human Chemical-Genetic Interaction Map Project]

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======= TFAM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFAM
  * **<color #00a2e8>Official Name</color>**: transcription factor A, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7019|7019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00059|Q00059]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFAM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFAM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600438|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. {ECO:0000269|PubMed:1737790, ECO:0000269|PubMed:19304746, ECO:0000269|PubMed:20410300, ECO:0000269|PubMed:22037171, ECO:0000269|PubMed:22037172, ECO:0000269|PubMed:22841477}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial promoter sequence-specific DNA binding|
|transcription initiation from mitochondrial promoter|
|mitochondrial transcription|
|DNA binding, bending|
|transcription coactivator binding|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|heat shock protein binding|
|mitochondrial respiratory chain complex assembly|
|mitochondrial gene expression|
|DNA-templated transcription, initiation|
|mitochondrial matrix|
|chromatin binding|
|sequence-specific DNA binding|
|mitochondrion organization|
|protein-containing complex|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|cellular protein-containing complex assembly|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.7|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.7|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.73|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.85|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.97|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.99|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.07|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.08|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.13|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrp63|MRP63]]|0.619|
|[[:human genes:g:gfm1|GFM1]]|0.606|
|[[:human genes:v:vars2|VARS2]]|0.571|
|[[:human genes:m:mrpl3|MRPL3]]|0.556|
|[[:human genes:m:mrps18a|MRPS18A]]|0.543|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.543|
|[[:human genes:m:mrps14|MRPS14]]|0.542|
|[[:human genes:m:mrpl21|MRPL21]]|0.536|
|[[:human genes:n:nars2|NARS2]]|0.531|
|[[:human genes:s:sars2|SARS2]]|0.53|
|[[:human genes:y:yars2|YARS2]]|0.527|
|[[:human genes:t:tars2|TARS2]]|0.526|
|[[:human genes:d:dap3|DAP3]]|0.522|
|[[:human genes:m:mrps25|MRPS25]]|0.518|
|[[:human genes:m:mrpl33|MRPL33]]|0.517|
|[[:human genes:n:ndufa3|NDUFA3]]|0.515|
|[[:human genes:m:mrps21|MRPS21]]|0.511|
|[[:human genes:d:dars2|DARS2]]|0.509|
|[[:human genes:m:mrps9|MRPS9]]|0.502|
|[[:human genes:m:mars2|MARS2]]|0.5|
|[[:human genes:m:mrpl38|MRPL38]]|0.499|
|[[:human genes:m:mrps26|MRPS26]]|0.499|
|[[:human genes:m:mrps6|MRPS6]]|0.498|
|[[:human genes:m:mrpl47|MRPL47]]|0.498|
|[[:human genes:c:cox7b|COX7B]]|0.498|
|[[:human genes:t:trub2|TRUB2]]|0.496|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.495|
|[[:human genes:t:tufm|TUFM]]|0.494|
|[[:human genes:m:mrpl23|MRPL23]]|0.493|
|[[:human genes:q:qrsl1|QRSL1]]|0.492|
|[[:human genes:p:pnpt1|PNPT1]]|0.492|
|[[:human genes:m:mrps16|MRPS16]]|0.486|
|[[:human genes:m:mrpl53|MRPL53]]|0.486|
|[[:human genes:h:hars2|HARS2]]|0.484|
|[[:human genes:m:mrps5|MRPS5]]|0.484|
|[[:human genes:r:rars2|RARS2]]|0.483|
|[[:human genes:m:mrpl45|MRPL45]]|0.482|
|[[:human genes:m:mrps23|MRPS23]]|0.482|
|[[:human genes:m:mrps34|MRPS34]]|0.481|
|[[:human genes:f:fars2|FARS2]]|0.48|
|[[:human genes:c:cox16|COX16]]|0.475|
|[[:human genes:n:ndufb11|NDUFB11]]|0.475|
|[[:human genes:n:ndufa1|NDUFA1]]|0.473|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.47|
|[[:human genes:f:ftsj2|FTSJ2]]|0.47|
|[[:human genes:m:mrps33|MRPS33]]|0.468|
|[[:human genes:c:c10orf2|C10orf2]]|0.468|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.468|
|[[:human genes:b:bcs1l|BCS1L]]|0.467|
|[[:human genes:m:mrpl12|MRPL12]]|0.462|
|[[:human genes:m:mrps35|MRPS35]]|0.457|
|[[:human genes:m:mrpl42|MRPL42]]|0.457|
|[[:human genes:n:ndufv1|NDUFV1]]|0.454|
|[[:human genes:t:tefm|TEFM]]|0.454|
|[[:human genes:l:lars2|LARS2]]|0.452|
|[[:human genes:m:mrps2|MRPS2]]|0.452|
|[[:human genes:r:rpusd4|RPUSD4]]|0.451|
|[[:human genes:m:mtg2|MTG2]]|0.451|
|[[:human genes:p:ptcd3|PTCD3]]|0.449|
|[[:human genes:m:mrps7|MRPS7]]|0.449|
|[[:human genes:r:rbfa|RBFA]]|0.448|
|[[:human genes:p:pars2|PARS2]]|0.446|
|[[:human genes:p:polg2|POLG2]]|0.446|
|[[:human genes:s:sco2|SCO2]]|0.442|
|[[:human genes:m:mrps10|MRPS10]]|0.441|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.437|
|[[:human genes:n:ndufb9|NDUFB9]]|0.437|
|[[:human genes:w:wbscr16|WBSCR16]]|0.436|
|[[:human genes:p:pet112|PET112]]|0.434|
|[[:human genes:m:mrpl15|MRPL15]]|0.434|
|[[:human genes:n:ndufs2|NDUFS2]]|0.434|
|[[:human genes:m:mrpl24|MRPL24]]|0.433|
|[[:human genes:m:mrpl55|MRPL55]]|0.429|
|[[:human genes:s:selrc1|SELRC1]]|0.428|
|[[:human genes:m:mrps22|MRPS22]]|0.425|
|[[:human genes:n:ndufc2|NDUFC2]]|0.423|
|[[:human genes:m:mrpl13|MRPL13]]|0.423|
|[[:human genes:t:tomm20|TOMM20]]|0.422|
|[[:human genes:m:mrps12|MRPS12]]|0.421|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.421|
|[[:human genes:c:cox6b1|COX6B1]]|0.42|
|[[:human genes:m:mrpl20|MRPL20]]|0.42|
|[[:human genes:m:mrpl27|MRPL27]]|0.418|
|[[:human genes:m:mrpl43|MRPL43]]|0.418|
|[[:human genes:m:mrpl37|MRPL37]]|0.418|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.418|
|[[:human genes:m:mrpl39|MRPL39]]|0.418|
|[[:human genes:a:aars2|AARS2]]|0.417|
|[[:human genes:e:ears2|EARS2]]|0.417|
|[[:human genes:f:fastkd5|FASTKD5]]|0.412|
|[[:human genes:m:mrpl52|MRPL52]]|0.411|
|[[:human genes:m:mrps24|MRPS24]]|0.41|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.408|
|[[:human genes:c:cox15|COX15]]|0.408|
|[[:human genes:n:ndufs7|NDUFS7]]|0.408|
|[[:human genes:c:cox6c|COX6C]]|0.407|
|[[:human genes:a:acad9|ACAD9]]|0.404|
|[[:human genes:m:mrpl17|MRPL17]]|0.402|
|[[:human genes:m:mrpl28|MRPL28]]|0.4|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 89/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|2/26|
|breast|6/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|3/20|
|lung|11/75|
|lymphocyte|3/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 143
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFAM Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>