TFB1M [The Human Chemical-Genetic Interaction Map Project]

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======= TFB1M =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFB1M
  * **<color #00a2e8>Official Name</color>**: transcription factor B1, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51106|51106]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WVM0|Q8WVM0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFB1M&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFB1M|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607033|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. {ECO:0000269|PubMed:11809803, ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RrnaAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA (adenine-N6,N6-)-dimethyltransferase activity|
|rRNA methylation|
|rRNA modification|
|mitochondrial nucleoid|
|RNA methylation|
|RNA modification|
|rRNA processing|
|rRNA metabolic process|
|macromolecule methylation|
|ribosome biogenesis|
|methylation|
|mitochondrial matrix|
|ncRNA processing|
|mitochondrion organization|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|RNA processing|
|RNA binding|
|DNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.75|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.04|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.08|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cars2|CARS2]]|0.603|
|[[:human genes:l:lars2|LARS2]]|0.599|
|[[:human genes:n:nars2|NARS2]]|0.598|
|[[:human genes:p:pet117|PET117]]|0.588|
|[[:human genes:f:ftsj2|FTSJ2]]|0.569|
|[[:human genes:p:pet112|PET112]]|0.562|
|[[:human genes:q:qrsl1|QRSL1]]|0.556|
|[[:human genes:a:acad9|ACAD9]]|0.554|
|[[:human genes:m:mrpl45|MRPL45]]|0.554|
|[[:human genes:r:rars2|RARS2]]|0.549|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.549|
|[[:human genes:m:mtif2|MTIF2]]|0.547|
|[[:human genes:n:ndufc2|NDUFC2]]|0.545|
|[[:human genes:g:grsf1|GRSF1]]|0.544|
|[[:human genes:m:mrps21|MRPS21]]|0.541|
|[[:human genes:n:nsun4|NSUN4]]|0.538|
|[[:human genes:n:ndufa1|NDUFA1]]|0.538|
|[[:human genes:g:gfm1|GFM1]]|0.535|
|[[:human genes:c:coa3|COA3]]|0.534|
|[[:human genes:n:ndufb11|NDUFB11]]|0.531|
|[[:human genes:f:fastkd2|FASTKD2]]|0.531|
|[[:human genes:n:ndufs5|NDUFS5]]|0.53|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.53|
|[[:human genes:m:mrps25|MRPS25]]|0.529|
|[[:human genes:d:ddx28|DDX28]]|0.526|
|[[:human genes:r:rpusd3|RPUSD3]]|0.525|
|[[:human genes:m:mrps16|MRPS16]]|0.524|
|[[:human genes:p:ptcd3|PTCD3]]|0.522|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.521|
|[[:human genes:w:wars2|WARS2]]|0.519|
|[[:human genes:n:ndufs2|NDUFS2]]|0.519|
|[[:human genes:m:malsu1|MALSU1]]|0.518|
|[[:human genes:m:mterfd1|MTERFD1]]|0.518|
|[[:human genes:m:mettl17|METTL17]]|0.517|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.514|
|[[:human genes:n:nubpl|NUBPL]]|0.51|
|[[:human genes:n:ndufa3|NDUFA3]]|0.506|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.504|
|[[:human genes:n:ndufa11|NDUFA11]]|0.496|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.496|
|[[:human genes:m:mrp63|MRP63]]|0.495|
|[[:human genes:c:c1qbp|C1QBP]]|0.493|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.492|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.491|
|[[:human genes:m:mrps27|MRPS27]]|0.489|
|[[:human genes:a:aars2|AARS2]]|0.487|
|[[:human genes:c:cox20|COX20]]|0.487|
|[[:human genes:n:ndufb10|NDUFB10]]|0.487|
|[[:human genes:n:ndufb4|NDUFB4]]|0.487|
|[[:human genes:a:aifm1|AIFM1]]|0.486|
|[[:human genes:m:mrpl21|MRPL21]]|0.483|
|[[:human genes:p:pars2|PARS2]]|0.482|
|[[:human genes:n:ndufs1|NDUFS1]]|0.481|
|[[:human genes:p:polg2|POLG2]]|0.481|
|[[:human genes:d:dars2|DARS2]]|0.479|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.478|
|[[:human genes:m:mrps6|MRPS6]]|0.477|
|[[:human genes:m:mrpl49|MRPL49]]|0.476|
|[[:human genes:y:yars2|YARS2]]|0.476|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.475|
|[[:human genes:t:tmem261|TMEM261]]|0.475|
|[[:human genes:s:ssbp1|SSBP1]]|0.474|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.471|
|[[:human genes:t:tars2|TARS2]]|0.47|
|[[:human genes:r:rbfa|RBFA]]|0.468|
|[[:human genes:m:mrpl28|MRPL28]]|0.467|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.467|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.466|
|[[:human genes:n:ndufa2|NDUFA2]]|0.466|
|[[:human genes:m:mrpl53|MRPL53]]|0.466|
|[[:human genes:m:mrps22|MRPS22]]|0.465|
|[[:human genes:m:mrps15|MRPS15]]|0.465|
|[[:human genes:v:vars2|VARS2]]|0.463|
|[[:human genes:m:mrpl17|MRPL17]]|0.463|
|[[:human genes:m:mars2|MARS2]]|0.46|
|[[:human genes:m:mrpl43|MRPL43]]|0.459|
|[[:human genes:d:dap3|DAP3]]|0.458|
|[[:human genes:e:eral1|ERAL1]]|0.457|
|[[:human genes:m:mrps26|MRPS26]]|0.457|
|[[:human genes:p:polg|POLG]]|0.456|
|[[:human genes:r:rpusd4|RPUSD4]]|0.455|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.455|
|[[:human genes:c:c12orf65|C12orf65]]|0.453|
|[[:human genes:n:ndufb9|NDUFB9]]|0.453|
|[[:human genes:n:ndufb6|NDUFB6]]|0.451|
|[[:human genes:m:mto1|MTO1]]|0.451|
|[[:human genes:s:selrc1|SELRC1]]|0.451|
|[[:human genes:m:mrps14|MRPS14]]|0.45|
|[[:human genes:c:cox11|COX11]]|0.446|
|[[:human genes:m:mrps18b|MRPS18B]]|0.444|
|[[:human genes:h:hars2|HARS2]]|0.444|
|[[:human genes:s:sco1|SCO1]]|0.443|
|[[:human genes:m:mrps23|MRPS23]]|0.443|
|[[:human genes:r:rmnd1|RMND1]]|0.442|
|[[:human genes:c:chchd1|CHCHD1]]|0.441|
|[[:human genes:c:coa6|COA6]]|0.439|
|[[:human genes:p:prepl|PREPL]]|0.438|
|[[:human genes:m:mrpl44|MRPL44]]|0.437|
|[[:human genes:c:c10orf2|C10orf2]]|0.437|
|[[:human genes:n:ndufa10|NDUFA10]]|0.435|
|[[:human genes:s:sco2|SCO2]]|0.435|
|[[:human genes:e:ears2|EARS2]]|0.434|
|[[:human genes:n:ndufc1|NDUFC1]]|0.433|
|[[:human genes:t:tefm|TEFM]]|0.433|
|[[:human genes:m:mrpl3|MRPL3]]|0.432|
|[[:human genes:n:ndufs3|NDUFS3]]|0.431|
|[[:human genes:e:ecsit|ECSIT]]|0.43|
|[[:human genes:m:mrpl47|MRPL47]]|0.43|
|[[:human genes:p:polrmt|POLRMT]]|0.43|
|[[:human genes:n:ndufv1|NDUFV1]]|0.43|
|[[:human genes:n:ndufa13|NDUFA13]]|0.43|
|[[:human genes:m:mrps5|MRPS5]]|0.429|
|[[:human genes:m:mrps10|MRPS10]]|0.429|
|[[:human genes:c:cox18|COX18]]|0.427|
|[[:human genes:w:wbscr16|WBSCR16]]|0.427|
|[[:human genes:m:mrps7|MRPS7]]|0.427|
|[[:human genes:m:mrpl35|MRPL35]]|0.425|
|[[:human genes:p:pnpt1|PNPT1]]|0.425|
|[[:human genes:a:atp5sl|ATP5SL]]|0.423|
|[[:human genes:m:mrpl23|MRPL23]]|0.423|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.422|
|[[:human genes:m:mrps9|MRPS9]]|0.421|
|[[:human genes:c:clpp|CLPP]]|0.42|
|[[:human genes:c:cox19|COX19]]|0.418|
|[[:human genes:g:gfm2|GFM2]]|0.417|
|[[:human genes:m:mterfd2|MTERFD2]]|0.417|
|[[:human genes:m:mcat|MCAT]]|0.417|
|[[:human genes:n:ndufb7|NDUFB7]]|0.413|
|[[:human genes:n:ndufv2|NDUFV2]]|0.412|
|[[:human genes:m:mrpl1|MRPL1]]|0.412|
|[[:human genes:c:cox16|COX16]]|0.411|
|[[:human genes:a:atp5c1|ATP5C1]]|0.408|
|[[:human genes:t:tsfm|TSFM]]|0.405|
|[[:human genes:t:tomm7|TOMM7]]|0.405|
|[[:human genes:m:mrpl22|MRPL22]]|0.405|
|[[:human genes:t:trit1|TRIT1]]|0.404|
|[[:human genes:n:ndufa5|NDUFA5]]|0.403|
|[[:human genes:g:gatc|GATC]]|0.4|
|[[:human genes:m:mrpl33|MRPL33]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1615
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFB1M Expression in NALM6 Cells: 3.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>