TFDP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TFDP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFDP1
  * **<color #00a2e8>Official Name</color>**: transcription factor Dp-1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7027|7027]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14186|Q14186]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFDP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFDP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189902|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). {ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537, ECO:0000269|PubMed:8405995}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DP|
|E2F TDP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of fat cell proliferation|
|regulation of fat cell proliferation|
|anoikis|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|positive regulation of establishment of protein localization to mitochondrion|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|regulation of mitochondrial membrane permeability|
|RNA polymerase II transcription factor complex|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|regulation of establishment of protein localization to mitochondrion|
|signal transduction involved in cell cycle checkpoint|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|regulation of membrane permeability|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|regulation of DNA biosynthetic process|
|positive regulation of mitochondrion organization|
|G1/S transition of mitotic cell cycle|
|signal transduction by p53 class mediator|
|cell cycle G1/S phase transition|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|regulation of cell cycle G1/S phase transition|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|mitochondrial transport|
|negative regulation of cell cycle phase transition|
|protein domain specific binding|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|transcription coactivator activity|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|transcription factor binding|
|regulation of DNA metabolic process|
|positive regulation of cell cycle|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|epidermis development|
|mitochondrion organization|
|regulation of cell cycle phase transition|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|membrane organization|
|regulation of cellular localization|
|apoptotic process|
|positive regulation of transport|
|cell cycle process|
|regulation of protein localization|
|programmed cell death|
|cell death|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|mitochondrion|
|regulation of organelle organization|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.82|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.72|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.79|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.81|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.85|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.86|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.87|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.91|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.93|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.12|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.2|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|2.23|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.25|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.28|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.3|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.38|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.45|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.46|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.66|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.69|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.18|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.48|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:e2f2|E2F2]]|0.456|
|[[:human genes:t:tfdp2|TFDP2]]|0.451|
|[[:human genes:y:ylpm1|YLPM1]]|0.414|
|[[:human genes:e:e2f1|E2F1]]|0.409|
|[[:human genes:r:rps25|RPS25]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 26/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|1/25|
|breast|2/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|0/15|
|kidney|2/21|
|liver|0/20|
|lung|7/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15207
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFDP1 Expression in NALM6 Cells: 6.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>