TFRC [The Human Chemical-Genetic Interaction Map Project]

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======= TFRC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TFRC
  * **<color #00a2e8>Official Name</color>**: transferrin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7037|7037]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02786|P02786]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TFRC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TFRC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). {ECO:0000250, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M28|
|PA|
|TFR dimer|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transferrin receptor activity|
|HFE-transferrin receptor complex|
|positive regulation of bone remodeling|
|positive regulation of bone resorption|
|positive regulation of isotype switching|
|positive regulation of tissue remodeling|
|regulation of isotype switching|
|transferrin transport|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|positive regulation of DNA recombination|
|regulation of bone resorption|
|positive regulation of B cell proliferation|
|positive regulation of immunoglobulin production|
|osteoclast differentiation|
|regulation of bone remodeling|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|clathrin-coated vesicle membrane|
|clathrin-coated pit|
|extracellular vesicle|
|regulation of B cell proliferation|
|receptor internalization|
|cellular iron ion homeostasis|
|regulation of immunoglobulin production|
|iron ion transport|
|double-stranded RNA binding|
|regulation of tissue remodeling|
|virus receptor activity|
|iron ion homeostasis|
|positive regulation of T cell proliferation|
|viral entry into host cell|
|response to leukemia inhibitory factor|
|positive regulation of production of molecular mediator of immune response|
|cellular response to leukemia inhibitory factor|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|melanosome|
|entry into host cell|
|entry into host|
|regulation of DNA recombination|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|receptor metabolic process|
|cellular transition metal ion homeostasis|
|myeloid leukocyte differentiation|
|recycling endosome|
|transition metal ion transport|
|positive regulation of lymphocyte proliferation|
|transition metal ion homeostasis|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|positive regulation of leukocyte proliferation|
|regulation of production of molecular mediator of immune response|
|blood microparticle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|interaction with host|
|regulation of T cell proliferation|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|positive regulation of DNA metabolic process|
|basolateral plasma membrane|
|viral life cycle|
|positive regulation of T cell activation|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|endosome membrane|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|receptor-mediated endocytosis|
|cytoplasmic vesicle|
|positive regulation of cell-cell adhesion|
|early endosome|
|endosome|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|leukocyte differentiation|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|cellular response to drug|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|regulation of cell growth|
|positive regulation of cell activation|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|endocytosis|
|cellular metal ion homeostasis|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|cellular ion homeostasis|
|immune system development|
|regulation of growth|
|import into cell|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|viral process|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|cation transport|
|membrane organization|
|positive regulation of immune response|
|protein homodimerization activity|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|cellular response to cytokine stimulus|
|response to drug|
|identical protein binding|
|response to cytokine|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of developmental process|
|ion transport|
|RNA binding|
|integral component of plasma membrane|
|protein transport|
|peptide transport|
|amide transport|
|extracellular space|
|establishment of protein localization|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.66|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.12|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.96|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.72|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.85|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.09|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.71|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.508|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.487|
|[[:human genes:d:dnm2|DNM2]]|0.424|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.416|
|[[:human genes:p:prim1|PRIM1]]|0.415|
|[[:human genes:s:sf3a3|SF3A3]]|0.407|
|[[:human genes:s:sf3b1|SF3B1]]|0.405|
|[[:human genes:f:fancm|FANCM]]|0.404|
|[[:human genes:m:mak|MAK]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 417/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|27/28|
|bone|7/26|
|breast|27/33|
|central nervous system|8/56|
|cervix|1/4|
|colorectal|12/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|14/21|
|liver|6/20|
|lung|44/75|
|lymphocyte|15/16|
|ovary|11/26|
|pancreas|18/24|
|peripheral nervous system|7/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|14/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TFRC Expression in NALM6 Cells: 10.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>