TGFBRAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TGFBRAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TGFBRAP1
  * **<color #00a2e8>Official Name</color>**: transforming growth factor beta receptor associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9392|9392]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUH2|Q8WUH2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TGFBRAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TGFBRAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606237|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent association with SMAD4. The protein is also a component of mammalian CORVET, a multisubunit tethering protein complex that is involved in fusion of early endosomes. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. {ECO:0000269|PubMed:11278302, ECO:0000269|PubMed:9545258}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Clathrin|
|CNH|
|Vps39 2|
|Vps39 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CORVET complex|
|endosomal vesicle fusion|
|transforming growth factor beta receptor binding|
|SMAD binding|
|endosome to lysosome transport|
|vesicle fusion|
|organelle membrane fusion|
|organelle fusion|
|transforming growth factor beta receptor signaling pathway|
|lysosomal transport|
|membrane fusion|
|vacuolar transport|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|early endosome|
|vesicle organization|
|cellular response to growth factor stimulus|
|response to growth factor|
|intracellular membrane-bounded organelle|
|enzyme linked receptor protein signaling pathway|
|membrane organization|
|intracellular protein transport|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.9|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:brd2|BRD2]]|0.509|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.489|
|[[:human genes:r:rab5c|RAB5C]]|0.485|
|[[:human genes:v:vps8|VPS8]]|0.476|
|[[:human genes:p:psmb4|PSMB4]]|0.471|
|[[:human genes:a:atp6v0a2|ATP6V0A2]]|0.453|
|[[:human genes:d:dnm2|DNM2]]|0.448|
|[[:human genes:c:copb2|COPB2]]|0.442|
|[[:human genes:t:ticrr|TICRR]]|0.438|
|[[:human genes:c:copg1|COPG1]]|0.434|
|[[:human genes:g:gch1|GCH1]]|0.433|
|[[:human genes:c:copz1|COPZ1]]|0.432|
|[[:human genes:a:arcn1|ARCN1]]|0.425|
|[[:human genes:p:polr2g|POLR2G]]|0.424|
|[[:human genes:c:copa|COPA]]|0.423|
|[[:human genes:v:vps11|VPS11]]|0.421|
|[[:human genes:o:osbp|OSBP]]|0.42|
|[[:human genes:g:gid4|GID4]]|0.42|
|[[:human genes:s:sf3a1|SF3A1]]|0.418|
|[[:human genes:i:iscu|ISCU]]|0.417|
|[[:human genes:r:rrm2|RRM2]]|0.413|
|[[:human genes:r:rrp15|RRP15]]|0.412|
|[[:human genes:p:polr2j3|POLR2J3]]|0.405|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.405|
|[[:human genes:s:supt5h|SUPT5H]]|0.404|
|[[:human genes:c:ccdc94|CCDC94]]|0.404|
|[[:human genes:c:chd4|CHD4]]|0.403|
|[[:human genes:t:tceb3c|TCEB3C]]|0.402|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1710
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TGFBRAP1 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>