THADA [The Human Chemical-Genetic Interaction Map Project]

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======= THADA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THADA
  * **<color #00a2e8>Official Name</color>**: THADA armadillo repeat containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63892|63892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6YHU6|Q6YHU6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THADA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THADA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611800|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2428|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ATPase-coupled calcium transmembrane transporter activity|
|cytoplasmic side of endoplasmic reticulum membrane|
|negative regulation of endoplasmic reticulum calcium ion concentration|
|regulation of ATPase-coupled calcium transmembrane transporter activity|
|adaptive thermogenesis|
|endoplasmic reticulum calcium ion homeostasis|
|negative regulation of calcium ion transmembrane transporter activity|
|tRNA methylation|
|negative regulation of calcium ion transmembrane transport|
|negative regulation of calcium ion transport|
|negative regulation of ion transmembrane transporter activity|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|RNA methylation|
|tRNA modification|
|regulation of calcium ion transmembrane transporter activity|
|negative regulation of ion transmembrane transport|
|negative regulation of transmembrane transport|
|tRNA processing|
|lipid homeostasis|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|RNA modification|
|tRNA metabolic process|
|regulation of calcium ion transport|
|macromolecule methylation|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|methylation|
|regulation of cation transmembrane transport|
|ncRNA processing|
|regulation of metal ion transport|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|ncRNA metabolic process|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|RNA processing|
|cellular homeostasis|
|chemical homeostasis|
|negative regulation of molecular function|
|homeostatic process|
|RNA metabolic process|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.95|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.87|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.83|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.445|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15806
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THADA Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>