TIAM1 [The Human Chemical-Genetic Interaction Map Project]

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======= TIAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIAM1
  * **<color #00a2e8>Official Name</color>**: TIAM Rac1 associated GEF 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7074|7074]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13009|Q13009]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600687|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. {ECO:0000269|PubMed:20361982}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RBD|
|RhoGEF|
|PDZ|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Schwann cell chemotaxis|
|regulation of Schwann cell chemotaxis|
|NMDA selective glutamate receptor signaling pathway|
|positive regulation of Schwann cell migration|
|regulation of Schwann cell migration|
|extrinsic component of postsynaptic density membrane|
|regulation of modification of postsynaptic actin cytoskeleton|
|main axon|
|regulation of modification of postsynaptic structure|
|positive regulation of glial cell migration|
|regulation of dopaminergic neuron differentiation|
|regulation of modification of synaptic structure|
|regulation of glial cell migration|
|Rac guanyl-nucleotide exchange factor activity|
|positive regulation of dendritic spine morphogenesis|
|cell-cell contact zone|
|Rac protein signal transduction|
|regulation of non-canonical Wnt signaling pathway|
|ionotropic glutamate receptor signaling pathway|
|axonal growth cone|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|muscle hypertrophy|
|positive regulation of dendrite morphogenesis|
|regulation of dendritic spine morphogenesis|
|positive regulation of dendritic spine development|
|glutamate receptor signaling pathway|
|positive regulation of epithelial to mesenchymal transition|
|response to cocaine|
|receptor tyrosine kinase binding|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|neuron projection extension|
|extrinsic component of cytoplasmic side of plasma membrane|
|positive regulation of gliogenesis|
|Rho guanyl-nucleotide exchange factor activity|
|positive regulation of JUN kinase activity|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|response to anesthetic|
|regulation of epithelial to mesenchymal transition|
|positive regulation of axonogenesis|
|ephrin receptor signaling pathway|
|regulation of JUN kinase activity|
|developmental cell growth|
|cell growth|
|regulation of dendrite morphogenesis|
|kinase binding|
|positive regulation of protein binding|
|ruffle membrane|
|regulation of postsynapse organization|
|Wnt signaling pathway, planar cell polarity pathway|
|activation of GTPase activity|
|guanyl-nucleotide exchange factor activity|
|regulation of establishment of planar polarity|
|response to alkaloid|
|developmental growth involved in morphogenesis|
|regulation of gliogenesis|
|cell-matrix adhesion|
|non-canonical Wnt signaling pathway|
|positive regulation of chemotaxis|
|positive regulation of JNK cascade|
|regulation of Rho protein signal transduction|
|dendritic spine|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|lipid binding|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|cell-cell junction|
|regulation of insulin secretion|
|positive regulation of binding|
|regulation of morphogenesis of an epithelium|
|response to ammonium ion|
|regulation of axonogenesis|
|cell-substrate adhesion|
|regulation of JNK cascade|
|regulation of peptide hormone secretion|
|regulation of chemotaxis|
|regulation of synapse organization|
|regulation of protein binding|
|regulation of synapse structure or activity|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|microtubule binding|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|regulation of animal organ morphogenesis|
|positive regulation of MAP kinase activity|
|regulation of hormone secretion|
|positive regulation of neuron projection development|
|regulation of ERK1 and ERK2 cascade|
|muscle system process|
|response to xenobiotic stimulus|
|regulation of cell morphogenesis involved in differentiation|
|microtubule|
|small GTPase mediated signal transduction|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|neuronal cell body|
|regulation of binding|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|positive regulation of GTPase activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|protein localization to membrane|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell death|
|regulation of response to external stimulus|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7720
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIAM1 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>