TIMM10 [The Human Chemical-Genetic Interaction Map Project]

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======= TIMM10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM10
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26519|26519]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62072|P62072]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602251|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-Tim10 DDP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein transporter activity|
|mitochondrial intermembrane space protein transporter complex|
|TIM23 mitochondrial import inner membrane translocase complex|
|protein insertion into mitochondrial inner membrane|
|chaperone-mediated protein transport|
|establishment of protein localization to mitochondrial membrane|
|protein insertion into mitochondrial membrane|
|protein insertion into membrane|
|inner mitochondrial membrane organization|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial intermembrane space|
|chaperone binding|
|mitochondrial membrane organization|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|mitochondrial transport|
|establishment of protein localization to membrane|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to membrane|
|protein localization to organelle|
|zinc ion binding|
|membrane organization|
|protein homodimerization activity|
|sensory perception|
|intracellular protein transport|
|mitochondrion|
|nervous system process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.95|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.85|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.72|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.94|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg1|ALG1]]|0.458|
|[[:human genes:p:ppcs|PPCS]]|0.425|
|[[:human genes:p:pmm2|PMM2]]|0.421|
|[[:human genes:r:rft1|RFT1]]|0.419|
|[[:human genes:t:thg1l|THG1L]]|0.417|
|[[:human genes:p:ppp6c|PPP6C]]|0.412|
|[[:human genes:t:tpk1|TPK1]]|0.412|
|[[:human genes:t:timm22|TIMM22]]|0.409|
|[[:human genes:f:fh|FH]]|0.404|
|[[:human genes:r:rfk|RFK]]|0.402|
|[[:human genes:a:atxn10|ATXN10]]|0.401|
|[[:human genes:d:dpagt1|DPAGT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 716/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|19/20|
|lung|71/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 215
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM10 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>