TIMM22 [The Human Chemical-Genetic Interaction Map Project]

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======= TIMM22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM22
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29928|29928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y584|Q9Y584]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607251|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250|UniProtKB:Q12328}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tim17|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TIM22 mitochondrial import inner membrane insertion complex|
|mitochondrion targeting sequence binding|
|protein insertion into mitochondrial inner membrane|
|establishment of protein localization to mitochondrial membrane|
|protein transmembrane transporter activity|
|protein insertion into mitochondrial membrane|
|protein insertion into membrane|
|inner mitochondrial membrane organization|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial membrane organization|
|mitochondrial transport|
|establishment of protein localization to membrane|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to membrane|
|protein localization to organelle|
|membrane organization|
|intracellular protein transport|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.2|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.18|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.88|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.88|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.81|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.8|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.78|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.77|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.76|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.73|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.73|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.72|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.7|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.75|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.79|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.86|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.9|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.92|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.96|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.98|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rnmt|RNMT]]|0.524|
|[[:human genes:d:dpagt1|DPAGT1]]|0.52|
|[[:human genes:c:c19orf52|C19orf52]]|0.484|
|[[:human genes:p:pmm2|PMM2]]|0.477|
|[[:human genes:v:vma21|VMA21]]|0.476|
|[[:human genes:a:alg1|ALG1]]|0.476|
|[[:human genes:d:dolk|DOLK]]|0.473|
|[[:human genes:g:gfpt1|GFPT1]]|0.466|
|[[:human genes:u:utp23|UTP23]]|0.462|
|[[:human genes:t:thg1l|THG1L]]|0.459|
|[[:human genes:p:ppa2|PPA2]]|0.455|
|[[:human genes:z:zrsr2|ZRSR2]]|0.454|
|[[:human genes:g:gmppb|GMPPB]]|0.453|
|[[:human genes:r:rpp21|RPP21]]|0.45|
|[[:human genes:t:triap1|TRIAP1]]|0.449|
|[[:human genes:d:ddx20|DDX20]]|0.449|
|[[:human genes:b:bub3|BUB3]]|0.448|
|[[:human genes:d:dhrsx|DHRSX]]|0.439|
|[[:human genes:r:rtcb|RTCB]]|0.439|
|[[:human genes:a:atp5o|ATP5O]]|0.434|
|[[:human genes:h:hspd1|HSPD1]]|0.433|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.432|
|[[:human genes:k:kdsr|KDSR]]|0.431|
|[[:human genes:c:ccdc115|CCDC115]]|0.429|
|[[:human genes:s:srp14|SRP14]]|0.427|
|[[:human genes:r:rft1|RFT1]]|0.422|
|[[:human genes:m:med16|MED16]]|0.421|
|[[:human genes:m:mad2l1|MAD2L1]]|0.42|
|[[:human genes:u:ube2g2|UBE2G2]]|0.418|
|[[:human genes:l:lsm10|LSM10]]|0.417|
|[[:human genes:p:pik3r4|PIK3R4]]|0.416|
|[[:human genes:n:nsmce1|NSMCE1]]|0.415|
|[[:human genes:e:elp3|ELP3]]|0.415|
|[[:human genes:p:phb|PHB]]|0.415|
|[[:human genes:a:adsl|ADSL]]|0.414|
|[[:human genes:s:srd5a3|SRD5A3]]|0.413|
|[[:human genes:t:trmt5|TRMT5]]|0.412|
|[[:human genes:a:atxn10|ATXN10]]|0.411|
|[[:human genes:t:timm10|TIMM10]]|0.409|
|[[:human genes:r:rad1|RAD1]]|0.408|
|[[:human genes:u:uap1|UAP1]]|0.404|
|[[:human genes:a:alg6|ALG6]]|0.404|
|[[:human genes:s:sdha|SDHA]]|0.401|
|[[:human genes:d:dohh|DOHH]]|0.401|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.4|
|[[:human genes:o:oraov1|ORAOV1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 17/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2229
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM22 Expression in NALM6 Cells: 4.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>